E. L. F. Holzbaur

This study shows that hyperactive LRRK2 impairs synaptic vesicle precursor trafficking by phosphorylating RAB3A, leading to disrupted synaptic protein delivery and potential non-motor PD symptoms.

This study identifies spastin's role in enhancing microtubule dynamics to pattern axons for presynaptic cargo delivery in human neurons.

The paper investigates the regulation of axonal autophagosome transport by dynein activators JIP3/JIP4 and ARF6/RAB10 GTPases, showing their roles in motor complex formation and organelle trafficking.

This study identifies p62 and HSP27 as key regulators of lysophagy by forming phase-separated condensates at damaged lysosomes, linking their dysfunction to ALS pathogenesis.

The paper identifies NEMO recruitment to damaged mitochondria as a mechanism linking impaired mitophagy to NF-κB activation and inflammation.

The paper uses a quantitative model to analyze axonal autophagosome-lysosome dynamics, revealing limited fusion events and a two-step maturation process.

The paper identifies sequential dynein effector handoffs during axonal autophagosome transport and maturation, showing their role in motility and neuronal health.

This study determines the crystal structure of WIPI2 interacting with ATG16L1, revealing the molecular mechanism of ATG16L1 recruitment to the phagophore and its role in autophagy initiation.

This study examines how ALS and FTD-linked TBK1 mutations affect mitophagy, revealing that both TBK1 recruitment and kinase activity are necessary for mitochondrial clearance, with some mutations causing mitochondrial stress and others having limited impact.

This study shows KIF21B kinesin-4 motors navigate mixed polarity microtubules in dendrites through directional switching and microtubule dynamics regulation.

The paper introduces Cega, a single particle segmentation algorithm that improves particle tracking in noisy systems by using KL divergence to distinguish moving particles from background noise.