Oligomeric state of the ZIKV E protein defines protective immune responses.
S. W. Metz, A. Thomas, A. Brackbill, J. Forsberg, M. J. Miley, C. A. Lopez, H. M. Lazear, S. Tian, A. M. de Silva
This study shows that dimeric Zika E protein antigens induce stronger neutralizing antibodies than monomers, suggesting that mimicking viral quaternary structure improves subunit vaccine efficacy.
bioRxiv · Jun 18, 2019Microbiology