Author

C. A. Lopez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:proteomics· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

H. M. Lazear· 3 shared S. Gnanakaran· 2 shared A. Brackbill· 1 shared A. M. de Silva· 1 shared A. S. Miller· 1 shared A. Thomas· 1 shared A. Vargiu· 1 shared B. Nemmaru· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersMicrobiology

H. M. Lazear

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Predicting Permeation of Compounds across the Outer Membrane of P. aeruginosa Using Molecular Descriptors: Advantages and Limitations

P. D. Manrique, I. Leus, C. A. Lopez, J. Mehla, G. Malloci, S. Gervasoni, A. Vargiu, R. Kinthada, L. Herndon, N. Hengartner, J. K. Walker, V. Rybenkov, P. Ruggerone, H. Zgurskaya, S. Gnanakaran

This study identifies molecular descriptors predictive of compound permeation across P. aeruginosa outer membrane using physicochemical, docking, and MD simulation data.

bioRxiv · Sep 2, 2023 · PreprintBiophysics

Zika virus replicates in the vagina of mice with intact interferon signaling

C. A. Lopez, S. J. Dulson, H. M. Lazear

This study shows that Zika virus replicates in the vagina of wild-type mice with intact interferon signaling, but only under high progesterone conditions, highlighting a hormonal factor in susceptibility to vaginal infection.

bioRxiv · Feb 21, 2022Microbiology

Zika virus-specific IgM elicited during pregnancy exhibits ultrapotent neutralization

T. Singh, K.-K. Hwang, A. S. Miller, R. L. Jones, C. A. Lopez, C. Giuberti, M. A. Gladden, I. Miller, H. S. Webster, J. A. Eudailey, K. Luo, T. Von Holle, R. J. Edwards, S. Valencia, K. E. Burgomaster, , M. Bonsignori

This study identifies a potent ZIKV-neutralizing IgM antibody from a pregnant woman and shows its protective efficacy in mice.

bioRxiv · Nov 23, 2021Immunology

Multiscale Characterization of Complex Binding Interactions of Cellulolytic Enzymes Highlights Limitations of Classical Approaches

S. P. S. Chundawat, B. Nemmaru, M. Hackl, S. K. Brady, M. A. Hilton, M. M. Johnson, S. Chang, M. J. Lang, H. Huh, S.-H. Lee, J. M. Yarbrough, C. A. Lopez, S. Gnanakaran

This study uses single-molecule assays and simulations to show how CBM1 binding affects cellulase activity on different cellulose allomorphs, highlighting limitations of classical binding models.

bioRxiv · May 8, 2020 · PreprintBiochemistry

Oligomeric state of the ZIKV E protein defines protective immune responses.

S. W. Metz, A. Thomas, A. Brackbill, J. Forsberg, M. J. Miley, C. A. Lopez, H. M. Lazear, S. Tian, A. M. de Silva

This study shows that dimeric Zika E protein antigens induce stronger neutralizing antibodies than monomers, suggesting that mimicking viral quaternary structure improves subunit vaccine efficacy.

bioRxiv · Jun 18, 2019Microbiology