A. Brock

Mathematical characterization of population dynamics in breast cancer cells treated with doxorubicin

This study develops a mathematical model to describe doxorubicin effects on MCF-7 breast cancer cells, showing that higher concentrations, shorter intervals, and more doses improve tumor control.

Quantification of long-term doxorubicin response dynamics in breast cancer cell lines to direct treatment schedules

This study quantifies how breast cancer cell lines respond to doxorubicin over time and identifies optimal treatment intervals to improve drug efficacy.

An experimental-mathematical approach to predict tumor cell growth as a function of glucose availability in breast cancer cell lines

The paper develops and validates a mathematical model to predict tumor cell growth based on glucose availability in breast cancer cell lines using experimental data.

Integrating multimodal data sets into a mathematical framework to describe and predict therapeutic resistance in cancer

This paper develops a framework integrating single-cell transcriptomic data with longitudinal treatment response data to predict drug resistance in breast cancer, achieving higher predictive accuracy with integrated data.

Expressed barcodes enable clonal characterization of chemotherapeutic responses in chronic lymphocytic leukemia

This paper develops a method to study clonal responses to chemotherapy in CLL by combining barcoding with single-cell RNA sequencing, revealing that rare drug-tolerant clones dominate post-treatment populations.

Stochastic Models for Revealing the Dynamics of the Growth of Small Tumor Populations

This paper presents a stochastic modeling framework to study altered growth dynamics in small tumor populations using high-throughput data.

Cancer cell population growth kinetics at low densities deviate from the exponential growth model and suggest an Allee effect

This paper investigates cancer cell growth at low densities and finds that an Allee effect model better describes growth kinetics than exponential growth, suggesting cooperative behavior among cells.