W. Zhang

Glucokinase links metabolism and lineage plasticity in neuroendocrine prostate cancer via interaction with AKT1

This study identifies glucokinase (GCK) as a metabolic enzyme that regulates lineage plasticity in neuroendocrine prostate cancer through its interaction with AKT1.

Iron Regulatory Protein 1 is Required for the Propagation of Inflammation in Inflammatory Bowel Disease

This study identifies IRP1 as a key driver of inflammation in IBD by linking iron homeostasis disruption to inflammatory propagation.

An effector XopL enhances ethylene biosynthesis to promote Xanthomonas fragariae infection in strawberry

This study identifies XopL as an effector that enhances ethylene biosynthesis in strawberry, promoting Xanthomonas fragariae infection by stabilizing FveACO9 and increasing ACO activity.

FLASH Irradiation Regulates IFN-β induction by mtDNA via Cytochrome c Leakage

This study shows FLASH irradiation increases cytochrome c leakage from mitochondria in normal cells, reducing mtDNA accumulation and IFN-β secretion, while having the opposite effect in cancer cells.

Determining the Youngs Modulus of the Bacterial Cell Envelope

The paper measures the Young's modulus of bacterial cell envelopes in E. coli, V. cholerae, and S. aureus using a microfluidic system and inverse finite element analysis, finding values ranging from 0.12 to 2.06 MPa.

Pro-renin Receptor Inhibited ABCA1/G1 Expression Associated with Low HDL-c and Promoted Atherosclerosis

This study shows that prorenin binding to (P)RR inhibits ABCA1/ABCG1 expression and cholesterol efflux, leading to dyslipidemia and atherosclerosis in hypertension.

Feather degradation in Stenotrophomonas maltophilia relies on conversion and internalization of keratin monomer

This study shows Stenotrophomonas maltophilia degrades feathers by converting them into keratin monomers, which enter cells to trigger keratinase activity and complete hydrolysis.

Characterization of Genome-wide Phylogenetic Conflict Uncovers Evolutionary Modes of Carnivorous Fungi

The paper uses phylogenomic analyses of 23 genomes to study evolutionary modes of carnivorous fungi, finding extensive phylogenetic discordance due to incomplete lineage sorting and non-vertical evolution.

The Genomes of Nematode-Trapping Fungi Provide Insights into the Origin and Diversification of Fungal Carnivorism

This study compares the genomes of nematode-trapping fungi and non-NTF to identify genomic changes linked to carnivorism and adaptation to post-Permian-Triassic extinction environments.

Effects of arbuscular mycorrhizal fungi on nitrogen uptake in cotton (Gossypium hirsutum L.) under low-nitrogen conditions

This study examines how arbuscular mycorrhizal fungi affect nitrogen uptake in cotton under low-nitrogen conditions, finding increased root biomass and soil enzyme activity with AMF symbiosis.

Role of Hepatocyte RIPK1 in Maintaining Liver Homeostasis during Metabolic Challenges

This study identifies RIPK1 in hepatocytes as critical for maintaining liver homeostasis during metabolic challenges, showing its role in preventing inflammation and apoptosis in mice.

Rapid in situ mutation detection in extracellular vesicle-DNA

This paper introduces a rapid, PCR- and sequencing-free DNA mutation detection method using CRISPR-Cas12a and extracellular vesicles for cancer diagnosis and treatment monitoring.

Shallow-water chemosymbiotic clams are a globally significant and previously overlooked carbon sink

This study identifies shallow-water chemosymbiotic clams as a significant, previously overlooked carbon sink in the Yellow Sea, contributing 43% of the region's sedimental carbon burial.

A Community Challenge to Predict Clinical Outcomes After Immune Checkpoint Blockade in Non-Small Cell Lung Cancer

The paper evaluates predictive models for immune checkpoint inhibitor outcomes in NSCLC using clinical trial data from two RCTs, finding that models combining PD-L1, TMB, and immune signatures outperform single biomarkers.

Prevalence and preferred niche of small eukaryotes with mixotrophic potentials in the global ocean

This study examines the prevalence and niche preferences of mixotrophic eukaryotes in the ocean, finding they thrive under low nutrients and light but depend on prey availability.

KDM6A Regulates Immune Response Genes in Multiple Myeloma

This study shows KDM6A regulates immune response genes in multiple myeloma by activating NLRC5 and CIITA, and its loss reduces MHC expression, which can be reversed by HDAC3 inhibitors.

The Xanthomonas fragariae effector XopK suppresses stomatal immunity by perturbing abscisic acid signaling in strawberry

This study identifies XopK, an effector from Xanthomonas fragariae, which suppresses stomatal immunity by disrupting abscisic acid signaling in strawberries, leading to increased susceptibility to infection.

Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination

This study identifies potent and broadly neutralizing antibodies against SARS-CoV-2 and related sarbecoviruses from a vaccinated donor, showing their efficacy against multiple variants and providing insights for therapeutic development.

Structural insights into agonist binding and activation of succinate receptor 1

This study presents cryo-EM structures of SUCNR1-Gi complexes bound to succinate and epoxysuccinate, revealing key residues and structural changes involved in agonist binding and activation.

Cryo-EM structures of human cone visual pigments

This study presents cryo-EM structures of human cone visual pigments in complex with G proteins, revealing their active state and mutations affecting spectral tuning.

In silico {lambda}-dynamics predicts protein binding specificities to modified RNAs

This paper uses in silico λ-dynamics to predict antibody binding specificities to RNA modifications, showing high agreement with experimental results.

Computation-aided Design of Rod-Shaped Janus Base Nanopieces for Improved Tissue Penetration and Therapeutics Delivery

This study develops rod-shaped Janus base nanopieces for improved tissue penetration and therapeutics delivery, showing better efficacy than spherical lipid nanoparticles in ovarian cancer models.

LRG1 promotes atherosclerosis by activating macrophages

This study identifies LRG1 as a pro-inflammatory factor in atherosclerosis by promoting macrophage M1 polarization through ERK and JNK pathways, and shows that LRG1 inhibition reduces atherosclerosis progression.

Neutralizing gut-derived lipopolysaccharide as a novel therapeutic strategy for severe leptospirosis

This study identifies gut-derived lipopolysaccharide (LPS) as a therapeutic target in severe leptospirosis, showing that neutralizing LPS improves survival when combined with antibiotics or antibodies.

A Germinal Center Checkpoint of AIRE in B Cells Limits Antibody Diversification

This study identifies AIRE as a checkpoint in germinal center B cells that limits antibody diversification by inhibiting AID function, leading to autoimmunity and impaired immune responses.

Feedback loop regulation between viperin and viral hemorrhagic septicemia virus through competing protein degradation pathways

This study identifies a feedback loop between viperin and VHSV where viperin degrades viral proteins via autophagy, while viral N protein suppresses viperin via proteasome degradation.

Linkers in bitopic agonists shape bias profile among transducers for the dopamine D2 and D3 receptors

The paper analyzes bitopic ligands for dopamine D2 and D3 receptors, showing that linker structure and stereochemistry significantly influence transducer bias profiles.

RBM7 deficiency promotes breast cancer metastasis by coordinating MFGE8 splicing switch and NF-kB pathway

This study identifies RBM7 deficiency as a driver of breast cancer metastasis through MFGE8 splicing regulation and NF-kB pathway suppression.

Cryo-EM structure and biochemical analysis of human chemokine receptor CCR8

The paper determines the cryo-EM structure of ligand-free human CCR8-Gi complex and identifies key residues for agonist recognition.

Structural basis for constitutive activation and CXCL1 recognition of human herpesvirus 8-encoded G protein-coupled receptor KSHV-GPCR

This study determines the cryo-EM structures of KSHV-GPCR in complex with Gi and CXCL1, revealing structural mechanisms of constitutive activation and ligand binding.