Author

A. Broom

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 2 Research Focus:drug response / drug discovery· 1 Research Focus:protein design· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

R. A. Chica· 2 shared A. M. Damry· 1 shared E. Nguyen· 1 shared J. S. Fraser· 1 shared L. Liu· 1 shared M. C. Thompson· 1 shared M. M. Mayer· 1 shared N. K. Goto· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiophysics

R. A. Chica

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2 papers

Recent·Most cited

Evolution of an enzyme conformational ensemble guides design of an efficient biocatalyst

A. Broom, R. V. Rakotoharisoa, M. C. Thompson, N. Zarifi, E. Nguyen, N. Mukhametzhanov, L. Liu, J. S. Fraser, R. A. Chica

The paper uses X-ray crystallography to study conformational changes in an evolved enzyme, leading to the design of a more efficient biocatalyst by focusing on active-site mutations.

bioRxiv · Mar 19, 2020Biophysics

Origin of Conformational Dynamics in a Globular Protein

A. M. Damry, M. M. Mayer, A. Broom, N. K. Goto, R. A. Chica

This study shows how two mutations can create conformational dynamics in a globular protein through synergistic effects on its energy landscape.

bioRxiv · Aug 4, 2019Biophysics