Disruption of the microphysiological niche alters matrix deposition and causes loss of mitochondrial Ca2+ control in skeletal muscle fibers
C. Gineste, S. Youhanna, S. U. Vorrink, S. Henriksson, A. Hernandez, A. J. Cheng, T. Chaillou, A. Buttgereit, D. Schneidereit, O. Friedrich, K. Hultenby, J. D. Bruton, N. Ivarsson, L. Sandblad, V. M. Lauschke, H. Westerblad
This study shows that disrupting the extracellular matrix in skeletal muscle fibers leads to mitochondrial Ca2+ uptake issues and dystrophic gene expression, which can be mitigated by Ppif inhibitors.
bioRxiv · Mar 29, 2021 · PreprintCell Biology