A. Hernandez

Mapping the breast tumor microenvironment: proximity analysis reveals spatial relationships between macrophage subtypes and metastasis-initiating cancer cells

The paper uses spatial analysis to show metastasis-initiating cancer cells in breast tumors are closely associated with specific macrophage subtypes, suggesting these interactions promote metastasis.

Chitosan induces salicylic acid local and systemically in banana plants and reduces colonization by the pathogen Fusarium oxysporum f. sp. cubense TR4

This study shows chitosan induces salicylic acid and reduces Fusarium oxysporum f. sp. cubense TR4 colonization in banana plants, with enhanced effects when combined with a biocontrol fungus.

Liver fibrosis uncouples tumor control from survival after multikinase inhibitor immunotherapy in hepatocellular carcinoma

Liver fibrosis limits the survival benefit of multikinase inhibitor immunotherapy in hepatocellular carcinoma by promoting innate immune-mediated hepatotoxicity despite preserved tumor control.

Immune landscape of tertiary lymphoid structures in hepatocellular carcinoma (HCC) treated with neoadjuvant immune checkpoint blockade

This study examines TLS in HCC treated with neoadjuvant immunotherapy, finding TLS correlate with better outcomes and show distinct morphological and functional features in tumor regression.

Monoclonal antibody chP3R99 reduces subendothelial retention of atherogenic lipoproteins in Insulin-Resistant rats: Acute treatment versus long-term protection as an idiotypic vaccine for atherosclerosis

This study shows that chP3R99 reduces lipoprotein retention in insulin-resistant rats through acute treatment or long-term vaccination, with no adverse metabolic effects.

Beyond the MEP Pathway: a novel kinase required for prenol utilization by malaria parasites

This study identifies a novel kinase in malaria parasites that enables prenol salvage, showing its role in bypassing MEP pathway inhibition and enhancing drug efficacy.

Functional traits of young seedlings predict trade-offs in seedling performance in three neotropical forests.

The paper shows that seedling functional traits and cotyledon strategy predict performance trade-offs across three tropical forests.

MyD88-Dependent Signaling Drives Toll-Like Receptor-Induced Trained Immunity in Macrophages

This study shows that MyD88-dependent signaling is critical for TLR-mediated trained immunity in macrophages, as demonstrated through experiments in mice and human cells.

Mathematical expressions describing enzyme velocity and inhibition at high enzyme concentration

The paper derives mathematical expressions for enzyme activity at high concentrations, extending classical Michaelis-Menten equations to account for inhibition and allosteric effects.

Relationship between bacterial phylotype and specialized metabolite production in the culturable microbiome of two freshwater sponges

The paper analyzes bacterial phylotype and specialized metabolite production in two freshwater sponges to show species-level variation in SM production and the need for detailed analysis.

High efficacy of therapeutic equine hyperimmune antibodies against SARS CoV-2 variants of concern

This study demonstrates that therapeutic equine polyclonal antibodies effectively neutralize SARS-CoV-2 variants of concern.

Disruption of the microphysiological niche alters matrix deposition and causes loss of mitochondrial Ca2+ control in skeletal muscle fibers

This study shows that disrupting the extracellular matrix in skeletal muscle fibers leads to mitochondrial Ca2+ uptake issues and dystrophic gene expression, which can be mitigated by Ppif inhibitors.

Development and pre-clinical characterization of two therapeutic equine formulations towards SARS-CoV-2 proteins for the potential treatment of COVID-19

This paper develops and pre-clinically evaluates two equine-derived anti-SARS-CoV-2 polyclonal formulations for potential COVID-19 treatment, showing high neutralizing capacity against SARS-CoV-2 infection.

Does participation in acoustic experiments provide enrichment to animals under human care? A case study of three grey seals (Halichoerus grypus)

This study assesses whether participation in acoustic experiments enriches grey seals, finding mixed results based on individual personality and life history.