Cell BiologybioRxivPreprint
Disruption of the microphysiological niche alters matrix deposition and causes loss of mitochondrial Ca2+ control in skeletal muscle fibers
C. Gineste, S. Youhanna, S. U. Vorrink…·H. Westerblad
This study shows that disrupting the extracellular matrix in skeletal muscle fibers leads to mitochondrial Ca2+ uptake issues and dystrophic gene expression, which can be mitigated by Ppif inhibitors.
DOI 10.1101/2021.03.29.437546