Author

A. C. Pan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 3 Approach:biophysical modeling· 2 Assay:protein structure· 2 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

D. E. Shaw· 3 shared A. Ibanez-de-Opakua· 1 shared C. Campbell-Bezat· 1 shared D. Jacobson· 1 shared D. Sritharan· 1 shared F. Giordanetto· 1 shared K. Yatsenko· 1 shared M. Zweckstetter· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersBiophysics

D. E. Shaw

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Author profile →

3 papers

Recent·Most cited

Molecular basis of small-molecule binding to α-synuclein

P. Robustelli, A. Ibanez-de-Opakua, C. Campbell-Bezat, F. Giordanetto, S. Becker, M. Zweckstetter, A. C. Pan, D. E. Shaw

The paper uses molecular dynamics simulations to study small-molecule binding to α-synuclein, revealing dynamic interactions that align with experimental data.

bioRxiv · Jan 22, 2021Biophysics

Structural mechanism for Bruton’s tyrosine kinase activation at the cell membrane

Q. Wang, Y. Pechersky, S. Sagawa, A. C. Pan, D. E. Shaw

This study uses molecular dynamics simulations to show that PIP3 stabilizes Btk dimerization at the cell membrane, which is critical for Btk activation.

bioRxiv · Apr 18, 2018Biophysics

Atomic-level characterization of protein-protein association

A. C. Pan, D. Jacobson, K. Yatsenko, D. Sritharan, T. M. Weinreich, D. E. Shaw

The paper uses molecular dynamics simulations to study protein-protein association mechanisms, finding that native associations often involve dissociation and re-association near the native interface rather than extensive interfacial exploration.

bioRxiv · Apr 17, 2018Biophysics