S. Becker

Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens

This study identifies natural nucleosides as activators of PKA in trypanosomatid pathogens, showing they replace cAMP in allosteric regulation through specific binding to CNB domains.

Direct Antigen Presentation is the Canonical Pathway of Cytomegalovirus CD8 T-cell Priming Regulated by Balanced Immune Evasion Mounting a Strong Antiviral Response

This study investigates how CMV primes CD8 T cells, finding that balanced immune evasion supports optimal antiviral responses despite conflicting evidence on direct antigen presentation's role.

Immunotherapy of cytomegalovirus infection by low-dose adoptive transfer of antiviral CD8 T cells relies on substantial post-transfer expansion of central memory cells but not effector-memory cells

Autoinhibition in the Signal Transducer CIN85 Modulates B Cell Activation

This study identifies an intramolecular SH3:PRM interaction in CIN85 that modulates its valency and phase separation, affecting B cell activation.

Quantitative description of the phase separation behavior of the multivalent SLP65-CIN85 complex

The paper quantifies SH3-PRM interactions in SLP65/CIN85 complexes and models their phase separation behavior using LASSI, revealing an intramolecular interaction.

Extracellular release of a disintegrin and metalloproteinases orchestrates periodontal disease severity

The paper investigates the role of ADAM8 and ADAM10 in periodontal disease by analyzing their expression and activity in patients and in vitro models, finding that ADAM8 dysregulation may drive disease progression.

Direct optical measurement of intra-molecular distances down to the Angstrom scale

This paper demonstrates that MINFLUX fluorescence nanoscopy can measure intra-molecular distances down to 1 Angstrom with high precision, validated using known protein distances and subunit orientations.

Real-time tracking of drug binding to Influenza A M2 reveals a high energy barrier

This paper investigates drug binding kinetics to Influenza A M2 protein using NMR, revealing a high energy barrier for pore binding and structural changes affecting solubility.

No substantial pre-existing B cell immunity against SARS-CoV-2 in healthy adults

The paper analyzes B cell immunity in unexposed adults and finds no substantial pre-existing antibody or B cell response to SARS-CoV-2.

Structural insight into Marburg virus nucleoprotein-RNA complex formation

This study determines the structure of the Marburg virus NP-RNA complex using cryo-EM, revealing conserved residues critical for nucleocapsid formation and RNA synthesis between MARV and EBOV.

Intranasal administration of a monoclonal neutralizing antibody protects mice against SARS-CoV-2 infection

This paper describes a monoclonal antibody, DZIF-10c, that effectively neutralizes SARS-CoV-2 and its variants when administered intranasally to mice, offering potential for topical treatment.

Nucleocapsid vaccine elicits spike-independent SARS-CoV-2 protective immunity

This study shows that a nucleocapsid protein vaccine provides protective immunity against SARS-CoV-2, independent of spike protein targeting, in animal models.

An Activator Locks Kv7.1 Channels Open by Electro-Mechanical Uncoupling and Allosterically Modulates its Pore with similarity to phosphatidylinositol-4,5-bisphosphat

This study identifies two independent mechanisms by which (R)-L3 activates Kv7.1 channels, involving allosteric modulation of the pore and electro-mechanical uncoupling.

Molecular basis of small-molecule binding to α-synuclein

The paper uses molecular dynamics simulations to study small-molecule binding to α-synuclein, revealing dynamic interactions that align with experimental data.

Immunogenicity and efficacy of the COVID-19 candidate vector vaccine MVA SARS 2 S in preclinical vaccination

This paper describes the preclinical evaluation of MVA-SARS-2-S, a vector vaccine against SARS-CoV-2, showing it induces immune responses and protects mice from infection.

RNA-Seq Time Series of Vitis vinifera Bud Development Reveals Correlation of Expression Patterns with the Local Temperature Profile

The paper generates an RNA-Seq time series dataset of grapevine bud development and finds a correlation between increased temperatures and heat-shock protein gene expression, with a developmental switch in July.

Inhibiting coronavirus replication in cultured cells by chemical ER stress

This study shows that thapsigargin inhibits coronavirus replication by modulating ER stress and quality control pathways in cultured cells.

Longitudinal isolation of potent near-germline SARS-CoV-2-neutralizing antibodies from COVID-19 patients

This study isolates potent SARS-CoV-2-neutralizing antibodies from COVID-19 patients as early as 8 days post-diagnosis and identifies precursor B cells in healthy individuals.

Ebola and Marburg virus matrix layers are locally ordered assemblies of VP40 dimers

The paper determines the structure of VP40 matrix layers in Ebola and Marburg virus-like particles, revealing they are locally ordered assemblies of VP40 dimers forming 2D lattices.

Non-canonical proline-tyrosine interactions with multiple host proteins regulate Ebola virus infection

This study identifies non-canonical proline-tyrosine interactions in the Ebola virus VP30 protein that regulate viral replication by interacting with multiple host proteins.

TMPRSS2 and furin are both essential for proteolytic activation and spread of SARS-CoV-2 in human airway epithelial cells and provide promising drug targets

This study shows TMPRSS2 and furin are both critical for SARS-CoV-2 activation in human airway cells and that inhibiting them can effectively block virus replication.

Imidazole-imidazole hydrogen bonding in the pH sensing Histidine sidechains of Influenza A M2

The paper shows that imidazole rings in the pH-sensing histidine sidechains of Influenza A M2 are hydrogen bonded at pH 7.8 in the neutral charge state.

Serine-arginine protein kinase 1 regulates Ebola virus transcription

This study identifies SRPK1 and SRPK2 as kinases that phosphorylate VP30, a key transcription factor for Ebola virus, and shows that disrupting this interaction impairs viral replication.