Cancer BiologybioRxiv
The Synergism Between DHODH Inhibitors and Dipyridamole Leads to Metabolic Lethality in Acute Myeloid Leukemia
V. Gaidano, M. Houshmand, N. Vitale…·P. Circosta
This study shows that combining a DHODH inhibitor with dipyridamole induces metabolic lethality and apoptosis in AML cells, overcoming pyrimidine salvage pathway resistance.
DOI 10.3390/cancers13051003