Adaptation to volumetric compression drives hepatoblastoma cells to an apoptosis-resistant and invasive phenotype
X. Gong, N. Ogino, M. F. Leite, Z. Chen, R. Liu, E. Kruglov, K. Flores, A. Cabral, G. M. M. Mendes, B. E. Ehrlich, M. Mak
This study shows that volumetric compression in liver cancer cells leads to transcriptional reprogramming, increased invasiveness, and chemoresistance, with potential reversal via calcium signaling.
bioRxiv · Oct 8, 2023 · PreprintCancer Biology