The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis
G. R. Carrat, E. Haythorne, A. Tomas, L. Haataja, A. Mueller, P. Arvan, A. Piunti, K. Cheng, M. Huang, T. Pullen, E. Georgiadou, T. Stylianides, N. S. Amirruddin, V. Salem, W. Distaso, , G. A. Rutter
This study identifies STARD10 as a phosphoinositide binding protein that regulates insulin granule biogenesis in beta-cells by affecting phosphatidylinositol levels and proinsulin processing.
bioRxiv · Mar 25, 2020Cell Biology