Author

E. Georgiadou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Assay:electronic health records· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

G. A. Rutter· 4 shared I. Leclerc· 3 shared E. Haythorne· 2 shared P. Chabosseau· 2 shared V. Salem· 2 shared A. C. H. Fung· 1 shared A. Cakebread· 1 shared A. K. K. Teo· 1 shared

Activity by Year

2019-2023 · peak 2/yr

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10 top collaborators · 29 mutual co-author links

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4 shared papersCell Biology

G. A. Rutter

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4 papers

Recent·Most cited

Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity

V. Yu, F. Yong, A. Marta, S. Khadayate, A. Osakwe, S. Bhattacharya, S. S. Varghese, P. Chabosseau, S. M. Tabibi, K. Chen, E. Georgiadou, N. Parveen, M. Suleiman, Z. Stamoulis, L. Marselli, , S. J. Millership

This study identifies differential CpG methylation at the Nnat gene as a mechanism establishing beta cell heterogeneity during development and its potential role in diabetes.

bioRxiv · Feb 4, 2023Cell Biology

The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis

G. R. Carrat, E. Haythorne, A. Tomas, L. Haataja, A. Mueller, P. Arvan, A. Piunti, K. Cheng, M. Huang, T. Pullen, E. Georgiadou, T. Stylianides, N. S. Amirruddin, V. Salem, W. Distaso, , G. A. Rutter

This study identifies STARD10 as a phosphoinositide binding protein that regulates insulin granule biogenesis in beta-cells by affecting phosphatidylinositol levels and proinsulin processing.

Molecular Metabolism · Oct 1, 2020Peer-reviewedCell Biology

Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice

E. Akalestou, K. Suba, L. Lopez-Noriega, E. Georgiadou, P. Chabosseau, I. Leclerc, V. Salem, G. A. Rutter

This study uses intravital imaging to show that bariatric surgery enhances β cell connectivity and Ca2+ dynamics in mice, leading to improved glucose tolerance and insulin secretion.

bioRxiv · May 5, 2020Cell Biology

The mitochondrial Ca2+ uniporter MCU is required for normal glucose-stimulated insulin secretion in vitro and in vivo

E. Haythorne, E. Georgiadou, M. Dickerson, L. Lopez Noriega, T. J. Pullen, G. da Silva Xavier, S. Davis, A. Martinez-Sanchez, F. Semplici, R. Rizzuto, J. A. McGinty, P. M. French, M. C. Cane, D. A. Jacobson, I. Leclerc, G. A. Rutter

This study shows that the mitochondrial Ca2+ uniporter MCU is essential for normal glucose-stimulated insulin secretion in pancreatic beta-cells, both in vitro and in vivo.

bioRxiv · Sep 25, 2019Physiology