Author

D. Hodson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 5 Physiology· 3 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Organism:mouse· 7 Assay:proteomics· 5 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell-cell communication· 2

Frequent Co-Authors

A. Tomas· 7 shared B. Jones· 7 shared J. Broichhagen· 6 shared S. R. Bloom· 5 shared G. A. Rutter· 4 shared M. Lucey· 4 shared P. Pickford· 4 shared I. R. Correa· 3 shared

Activity by Year

2019-2021 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

7 shared papersPharmacology & Toxicology

A. Tomas

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Author profile →

10 papers

Recent·Most cited

Evaluation of efficacy- versus affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F1

A. Marzook, S. Chen, P. Pickford, M. Lucey, Y. Wang, I. R. Correa, J. Broichhagen, D. Hodson, V. Salem, G. A. Rutter, T. M. Tan, S. R. Bloom, A. Tomas, B. Jones

This study compares the efficacy and affinity of two GLP-1R agonists, P5 and exendin-F1, showing that exendin-F1's lower acute efficacy correlates with sustained insulin secretion and anti-hyperglycaemic effects.

bioRxiv · Apr 1, 2021Pharmacology & Toxicology

Acylation of the incretin peptide exendin-4 directly impacts GLP-1 receptor signalling and trafficking

M. Lucey, T. Ashik, A. Marzook, Y. Wang, J. Goulding, A. Oishi, J. Broichhagen, D. Hodson, J. Minnion, Y. Elani, R. Jockers, S. J. Briddon, S. R. Bloom, A. Tomas, B. Jones

This study compares exendin-4 and its acylated variant exendin-4-C16, showing acylation affects GLP-1R signaling bias, trafficking, and pharmacokinetics.

bioRxiv · Apr 1, 2021Pharmacology & Toxicology

Sulfonated rhodamines as impermeable labelling substrates for cell surface protein visualization

R. Birke, J. Ast, D. A. Roosen, B. Mathes, K. Rossmann, C. Huhn, B. Jones, M. Lehmann, V. Haucke, D. Hodson, J. Broichhagen

The paper introduces sulfonated rhodamines as impermeable dyes for cell surface protein labeling, validated in live cell imaging and STED nanoscopy.

bioRxiv · Mar 16, 2021 · PreprintBiochemistry

Partial agonism improves the anti-hyperglycaemic efficacy of an oxyntomodulin-derived GLP-1R/GCGR co-agonist

P. Pickford, M. Lucey, R.-M. Rujan, E. R. McGlone, S. Bitsi, F. Ashford, I. R. Correa, D. Hodson, A. Tomas, G. Deganutti, C. A. Reynolds, B. M. Owen, T. M. Tan, J. Minnion, S. R. Bloom, B. Jones

This study shows that partial agonism of GLP-1R/GCGR co-agonists improves anti-hyperglycaemic efficacy by reducing β-arrestin-2 recruitment, leading to prolonged glucose-lowering effects and comparable weight loss to liraglutide.

bioRxiv · Mar 2, 2021Pharmacology & Toxicology

Testosterone enhances GLP-1 efficacy at the plasma membrane and endosomes to augment insulin secretion in male pancreatic β cells

W. Xu, F. Ashford, S. Bitsi, L. Schiffer, F. Qadir, W. Arlt, A. Tomas, D. Hodson, F. Mauvais-Jarvis

This paper shows testosterone enhances GLP-1's ability to increase insulin secretion in male β cells by boosting cAMP production at the plasma membrane and endosomes.

bioRxiv · May 12, 2020 · PreprintPhysiology

The type 2 diabetes gene product STARD10 is a phosphoinositide binding protein that controls insulin secretory granule biogenesis

G. R. Carrat, E. Haythorne, A. Tomas, L. Haataja, A. Mueller, P. Arvan, A. Piunti, K. Cheng, M. Huang, T. Pullen, E. Georgiadou, T. Stylianides, N. S. Amirruddin, V. Salem, W. Distaso, , G. A. Rutter

This study identifies STARD10 as a phosphoinositide binding protein that regulates insulin granule biogenesis in beta-cells by affecting phosphatidylinositol levels and proinsulin processing.

bioRxiv · Mar 25, 2020Cell Biology

The influence of peptide context on signalling and trafficking of glucagon-like peptide-1 receptor biased agonists

Z. Fang, S. Chen, P. Pickford, J. Broichhagen, D. Hodson, I. R. Correa, S. Kumar, F. Gorlitz, C. Dunsby, P. French, G. A. Rutter, T. Tan, S. R. Bloom, A. Tomas, B. Jones

The paper evaluates how peptide context affects GLP-1R signaling and trafficking, showing differences in agonist-mediated responses based on sequence homology and structural features.

bioRxiv · Feb 24, 2020Pharmacology & Toxicology

Interrogating surface versus intracellular transmembrane receptor populations using cell-impermeable SNAP-tag substrates

P. Poc, V. A. Gutzeit, J. Ast, J. Lee, B. Jones, E. D'Este, B. Mathes, D. Hodson, J. Levitz, J. Broichhagen

The paper introduces SBG-conjugated fluorophores to improve extracellular labeling of SNAP-fused proteins, enabling precise analysis of GPCR populations in living cells and tissues.

bioRxiv · Jan 29, 2020Physiology

Differences in signalling, trafficking and glucoregulatory properties of glucagon-like peptide-1 receptor agonists exendin-4 and lixisenatide

P. Pickford, M. Lucey, Z. Fang, S. Bitsi, J. Broichhagen, D. Hodson, J. Minnion, G. A. Rutter, S. R. Bloom, A. Tomas, B. Jones

This study compares the signalling, trafficking, and glucoregulatory effects of exendin-4 and lixisenatide, finding differences in cAMP signalling potency and receptor recycling that impact glucose control.

bioRxiv · Oct 16, 2019Pharmacology & Toxicology

Maternal hypothyroidism in mice influences glucose metabolism in adult offspring

Y. Kemkem, D. Nasteska, D. Hodson, A. Guillou, P. Mollard, P. Bargi-Souza, R. A. Peliciari-Garcia, A. De Bray, M. Schaeffer

This study shows that maternal hypothyroidism in mice leads to altered glucose metabolism in adult offspring, with persistent effects across generations.

bioRxiv · Sep 28, 2019Physiology