Metabolic excretion associated with nutrient-growth dysregulation promotes the rapid evolution of an overt metabolic defect
R. Green, S. Sonal, W. Lu, L. Wang, S. F. Hart, D. Skelding, J. C. Burton, A. Capel, H. A. Chen, A. Lin, A. R. Subramaniam, J. D. Rabinowitz, W. Shou
The paper shows that nutrient-growth dysregulation in yeast leads to the evolution of a metabolic defect involving organosulfur release, which confers a fitness advantage under specific conditions.
bioRxiv · Apr 26, 2020Evolutionary Biology