A. Lin

PanCanSurvPlot: A Large-scale Pan-cancer Survival Analysis Web Application

PanCanSurvPlot provides a web tool for large-scale pan-cancer survival analysis with 215 datasets, 45,000 samples, and customizable survival plots.

Unraveling the Role of Ctla-4 in Intestinal Immune Homeostasis: Insights from a novel Zebrafish Model of Inflammatory Bowel Disease

This study identifies a zebrafish model of IBD by knocking out Ctla-4, showing similar intestinal inflammation and immune dysregulation to mammalian IBD.

HIV-1 controllers possess a unique CD8+ T-cell activation phenotype and loss of control is associated with increased expression of exhaustion markers

The paper examines CD8+ T-cell exhaustion in HIV-1 controllers and finds that loss of control correlates with increased exhaustion markers, which can be reversed by immune checkpoint blockade.

Blocker-SELEX: A Structure-guided Strategy for Developing Inhibitory Aptamers Disrupting Undruggable Transcription Factor Interactions

This paper introduces Blocker-SELEX, a structure-guided method to design inhibitory aptamers that disrupt transcription factor interactions, demonstrating efficacy against SCAF4/SCAF8-RNAP2 and WDR5-MYC complexes.

THER: Integrative Web Tool for Tumor Hypoxia Exploration and Research

THER is a web tool that integrates hypoxia-related transcriptomic data to analyze tumor hypoxia mechanisms and drug responses.

An immunohistochemical atlas of necroptotic pathway expression

The paper develops automated immunohistochemistry protocols to detect necroptotic pathway proteins in mouse and human tissues, revealing heterogeneity and disease-related changes in expression.

Single-cell RNA sequencing unveils the hidden powers of zebrafish kidney for generating both hematopoiesis and adaptive antiviral immunity

This study uses single-cell RNA sequencing to show zebrafish kidney cells can generate both blood cells and adaptive antiviral immunity, acting as a dual-functional organ.

Colchicine promotes atherosclerotic plaque stability independently of inflammation

This study shows colchicine stabilizes atherosclerotic plaques by converting harmful SMC-derived cells into protective myofibroblast-like cells, independent of its anti-inflammatory effects.

Novel Epidermal Oxysterols Function as Alarm Substances in Zebrafish

This study identifies two novel oxysterol sulfates in zebrafish skin that function as alarm substances, inducing anti-predator behaviors and increasing cortisol levels at sub-nanomolar concentrations.

Herpes zoster mRNA vaccine induces superior vaccine immunity over licensed vaccine in mice and rhesus macaques

This study compares a novel VZV mRNA vaccine (ZOSAL) with Shingrix in mice and rhesus macaques, showing ZOSAL induces stronger T cell immunity and safety.

β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain

This study identifies β-hydroxybutyrate as a metabolic regulator of protein solubility in aging and Alzheimer's disease, showing it reduces insolubility of pathological proteins like amyloid-β.

In vivo Ontogeny of human forebrain neural progenitor cell grafts in adult rats: an immunohistological study

This study tracks human neural progenitor cell grafts in adult rats up to 9 months, revealing their migration and differentiation patterns, and highlights their potential for neural repair.

GTP signaling links metabolism, DNA repair, and responses to genotoxic stress

This study identifies a GTP-mediated signaling pathway linking metabolism to DNA repair and resistance to genotoxic stress in glioblastoma and non-malignant cells.

Uncovering the hidden threat: single-organoid analysis reveals clinically relevant treatment-resistant and invasive subclones in pancreatic cancer

This study uses single-organoid analysis to identify treatment-resistant and invasive subclones in pancreatic cancer, correlating with patient outcomes and drug response.

A burns and COVID-19 shared stress responding gene network deciphers CD1C-CD141- DCs as the key cellular components in septic prognosis

The paper identifies a stress-response gene network linked to CD1C-CD141 dendritic cells that correlates with prognosis in burns and COVID-19.

Hatchling fish disperse using an efficient multisensory strategy

The paper shows hatchlings use a multisensory strategy to disperse efficiently in freshwater environments by adapting their behavior based on sensory feedback.

A therapeutic hepatitis B mRNA vaccine with strong immunogenicity and persistent virological suppression

This paper develops an mRNA vaccine for chronic hepatitis B that shows strong immunogenicity and persistent virological suppression in mouse models.

Ancestral reconstruction of the MotA stator subunit reveals that conserved residues far from the pore are required to drive flagellar motility

This study uses ancestral sequence reconstruction to identify conserved residues in MotA essential for flagellar motility across different bacterial species.

Kinetic and Structural Analysis of Ribonucleotide Extension by DNA Polymerase η

This study investigates how DNA polymerase η extends ribonucleotide-terminated primers, showing reduced fidelity and structural changes during extension.

The CD103-XCR1 axis mediates the recruitment of immunoregulatory dendritic cells after traumatic injury

The paper identifies the CD103-XCR1 axis as critical for recruiting immunoregulatory dendritic cells that promote tissue regeneration after traumatic injury.

Proteomic Dissection of a Giant Cell

The paper quantifies polarized protein localization in Stentor coeruleus by cutting cells along the anterior-posterior axis and analyzing proteomic enrichment, finding 30% of proteins show polarized localization.

TGS1: a novel regulator of β-cell mass and function

This study identifies TGS1 as a regulator of β-cell mass and function, showing its role in glucose homeostasis and response to high-fat diet through mechanisms involving ER stress and cell cycle regulation.

OrBITS: A High-throughput, time-lapse, and label-free drug screening platform for patient-derived 3D organoids

The paper introduces OrBITS, a software for automated live-cell imaging of organoids, validated against standard assays, and demonstrates its utility in drug screening and patient stratification.

Hexose translocation mediated by SlSWEET5b is required for pollen maturation in Solanum lycopersicum

This study identifies SlSWEET5b as a hexose transporter essential for pollen maturation in tomato by facilitating sugar translocation from phloem to anther cells and pollen.

Modular, Cascade-like Transcriptional Program of Regeneration in Stentor

This study uses RNAseq to analyze transcriptional changes during regeneration in Stentor coeruleus, identifying distinct gene expression modules and a cascade mechanism involving translation products of early-expressed genes.

High levels of truncated RHAMM cooperate with dysfunctional p53 to accelerate theprogression of pancreatic cancer

The rapid evolution of flagellar ion-selectivity in experimental populations of E. coli

The paper shows that E. coli can rapidly revert a CRISPR-induced Na+-powered flagellar motor to H+-powered by evolving new mutations, revealing adaptability and modularity of the motor complex.

Homology between the flagellar export apparatus and ATP synthetase: evidence from synteny predating the Last Universal Common Ancestor

The paper examines synteny between ATP synthetase and bacterial flagellar motor genes, finding deep conservation suggesting homology dating back to before LUCA.

TaqMan Array Cards enable monitoring of diverse enteric pathogens across environmental and host reservoirs

This study compares TaqMan Array Cards and standard qPCR for detecting enteric pathogens in diverse samples, finding comparable performance with TAC offering a broader panel at lower cost.

Generation of glucocorticoid resistant SARS-CoV-2 T-cells for adoptive cell therapy

The paper expands SARS-CoV-2 T-cells from COVID-19 donors using IL-2/4/7 cytokines, achieving >1000-fold expansion with preserved function, and inactivates the glucocorticoid receptor to create glucocorticoid-resistant T-cells for adoptive therapy.