Resource reallocation in engineered Escherichia coli strains with reduced genomes
R. Egbert, A. Chazin-Gray, E. S. Nakayasu, A. Eaton, R. Francis, D. Auberry, N. Munoz, J. Cottam, J. Zucker, N. Kumar, C. Nicora, H. Mitchell, Y.-M. Kim, W. C. Nelson
This study examines the effects of genome reduction in E. coli on proteome expression and stability of a biosynthetic pathway for pigment production, finding that proteome fraction elimination impacts fitness and bioproduction balance.
bioRxiv · Oct 19, 2020 · PreprintBioengineering