H. Mitchell

A unique subset of pericystic endothelium associates with aberrant microvascular remodelling and impaired blood perfusion early in polycystic kidney disease

The paper identifies a unique pericystic endothelium in ADPKD that contributes to microvascular remodelling and impaired perfusion, suggesting vascular targets for early intervention.

Modulation of Polar Auxin Transport Identifies the Molecular Determinants of Source-Sink Carbon Relationships and Sink Strength in Poplar

This study uses auxin modulators to investigate carbon allocation and sink strength in poplar, identifying molecular factors like polygalacturonase and β-amylase that influence sink activity.

Three-dimensional imaging and single-cell transcriptomics of the human kidney implicate perturbation of lymphatics in alloimmunity

This study uses 3D imaging and single-cell RNA-sequencing to analyze human kidney lymphatics, revealing structural and transcriptional changes in rejecting kidney transplants.

Microclimate is a strong predictor of the native and invasive plant-associated soil microbiota on San Cristobal Island, Galapagos archipelago

The paper investigates how microclimate influences soil microbial communities on San Cristobal Island, finding it is the strongest driver of bacterial and fungal diversity.

Resource reallocation in engineered Escherichia coli strains with reduced genomes

This study examines the effects of genome reduction in E. coli on proteome expression and stability of a biosynthetic pathway for pigment production, finding that proteome fraction elimination impacts fitness and bioproduction balance.

Strain population structure varies widely across bacterial species and predicts strain colonization in unrelated individuals

The study quantifies strain population sizes across bacterial species and finds prevalent strains in common gut microbiota are more likely to be shared among unrelated individuals.

Defined microbiota transplant restores Th17/RORtγ+ regulatory T cell balance in mice colonized with inflammatory bowel disease microbiotas

The paper shows that transplanting healthy microbiota into mice with IBD microbiotas restores Th17/RORγt+ regulatory T cell balance by reducing pathogenic strains.