N. Kumar

Dicarbonyl stress enhances tumor intravasation

This study shows dicarbonyl stress increases cancer cell intravasation by degrading ECM and promoting endothelial dysfunction in a microfluidic model.

Rosettes in a matrix: Predicting spatial variation in density of a large felid in a forest-production mosaic

This study estimates leopard densities in a tea-plantation and forest mosaic, finding higher densities in tea plantations than in forests, suggesting multi-use landscapes may support large felids better than protected areas.

Effect of developmental and adult diet composition on reproductive aging in Drosophila melanogaster

This study investigates how developmental and adult diet composition affects reproductive aging in Drosophila melanogaster, finding age-dependent impacts with independent effects of developmental and adult diets.

METTL3 drives telomere targeting of TERRA lncRNA through m6A-dependent R-loop formation: a therapeutic target for ALT-positive neuroblastoma

This study shows METTL3 modifies TERRA lncRNA with m6A, promoting R-loop formation that targets TERRA to telomeres, and inhibiting METTL3 disrupts this process in ALT+ neuroblastoma cells.

Development of a new genotype-phenotype linked antibody screening system

This paper develops a new antibody screening system using a Golden Gate-based dual-expression vector to rapidly isolate high-affinity cross-reactive antibodies from immunized mice.

Single nuclei multiomics reveals the drought-driven gene regulatory atlas in Arabidopsis

This study uses single-nucleus multiomics to uncover drought-driven gene regulatory mechanisms in Arabidopsis, identifying cell type-specific markers and regulatory networks.

Molecular heterogeneity of quiescent melanocyte stem cells revealed by single-cell RNA-sequencing.

This study uses single-cell RNA sequencing to reveal molecular heterogeneity in quiescent melanocyte stem cells and identifies novel subpopulations with distinct immune privilege and differentiation potential.

Unraveling molecular basis for reduced neuraminidase inhibitors susceptibility in highly pathogenic avian influenza A (H5N1) viruses isolated from chickens in India

This study identifies mutations in H5N1 avian influenza viruses that confer resistance to neuraminidase inhibitors, revealing their molecular mechanisms and implications for antiviral strategies.

Predicting Early Diabetic Kidney Disease Using a 3D Mesangial Model and Bayesian Mechano-Chemical Stratification

Non-canonical NF-κB signaling promotes intestinal inflammation by restraining the tolerogenic β-catenin-Raldh2 axis in dendritic cells

A novel highly divergent enteric calicivirus in a bovine calf, India

The paper reports a novel calicivirus found in an Indian bovine calf and highlights its divergence from known Neboviruses.

NK and NKT cells in the pathogenesis of Hidradenitis suppurativa: Novel therapeutic strategy through targeting of CD2

This study identifies expanded NKT and NK cells with elevated CD2 in HS lesions and shows CD2 blockade reduces inflammation and fibrosis.

p38-MAPK is prerequisite for the synthesis of SARS-CoV-2 protein

This study shows that p38-MAPK is essential for SARS-CoV-2 replication, as its inhibition reduces viral growth and its activation supports RNA/protein synthesis without affecting viral entry or budding.

MolPhase: An Advanced Phase Separation Predictor and an Investigation of Phytobacterial Effector in Plant

MolPhase predicts protein phase separation using physicochemical features and experimental data, showing T3Es undergo homotypic phase separation in vitro and in vivo.

A Light sheet fluorescence microscopy and machine learning-based approach to investigate drug and biomarker distribution in whole organs and tumors.

This paper uses light sheet fluorescence microscopy and machine learning to study drug and biomarker distribution in whole organs and tumors, showing improved segmentation accuracy and subcellular resolution.

Diet-induced plasticity of life-history traits and gene expression in outbred Drosophila melanogaster population

This study examines how different macronutrient diets affect life-history traits and gene expression in Drosophila melanogaster, finding that carbohydrate-reduced diets accelerate development and reproduction while high carbohydrate diets reduce lifespan.

Unravelling Genomic Origin of Lumpy Skin Disease Virus in Recent Outbreaks

This study uses whole genome sequencing to analyze genetic variations in Lumpy Skin Disease Virus (LSDV) from 2022 outbreaks, identifying key mutations and phylogenetic clusters linked to pathogenesis.

KLP-7/Kinesin-13 orchestrates axon-dendrite checkpoints for polarized trafficking in neurons

This study shows KLP-7/Kinesin-13 is essential for axon-dendrite compartmentalization by regulating microtubule dynamics and preventing mislocalization of axonal proteins in C. elegans neurons.

Changes in an Enzyme Ensemble During Catalysis Observed by High Resolution XFEL Crystallography

The paper uses XFEL crystallography to observe conformational changes in an enzyme during catalysis, revealing ionization-linked dynamics that control catalytic activity.

Ecological Impacts of Poultry Waste on Urban Raptors: Conflicts, Diseases, and Climate Change Implications amidst Pandemic Threats

This study examines the ecological and public health impacts of poultry production and consumption waste on urban raptors and scavengers in Delhi, highlighting climate, disease, and pandemic-related effects.

Faulty Metabolism: A Potential Instigator of an Aggressive Phenotype in Cdk5-dependent Medullary Thyroid Carcinoma

This study establishes mouse models of Cdk5-driven Medullary Thyroid Carcinoma (MTC) that recapitulate human tumor aggressiveness and identifies metabolic pathway perturbations as critical for aggressive growth.

Profiling sorghum-microbe interactions with a specialized photoaffinity probe identifies key sorgoleone binders in Acinetobacter pittii

This paper uses a sorgoleone-based photoaffinity probe to identify proteins in Acinetobacter pittii that bind sorgoleone, revealing potential pathways for microbial interaction with this plant metabolite.

Leveraging RAS-mSIN1 Interaction to Selectively Inhibit mTORC2 Employing Competitive RAS Binding Peptide: Implications in Breast Cancer Metastasis

The paper withdraws a manuscript due to incomplete experiments and requests that it not be cited as a reference.

Cryo- EM structure of the mycobacterial 70S ribosome in complex with ribosome hibernation promotion factor RafH, reveals the unique mode of mycobacterial ribosome hibernation

This paper reports the cryo-EM structure of the mycobacterial 70S ribosome complexed with RafH, revealing unique mechanisms of ribosome hibernation in mycobacteria.

Evaluation of the safety, immunogenicity and efficacy of a new live-attenuated lumpy skin disease vaccine in India

This study evaluates a new live-attenuated LSD vaccine, showing it is safe, immunogenic, and effective in protecting cattle against LSD with high seroconversion rates.

Genomic and ecologic characteristics of the airway microbial-mucosal complex

The paper characterizes the genomic and ecological features of the airway microbial-mucosal complex, identifying novel bacteria and functional pathways linked to lung diseases.

A novel fluorobenzothiazole RBx 10080758 as a dual inhibitor against bacterial GyraseB (GyrB) and Topoisomerase IV (parE) of Gram-positive pathogens causing skin and respiratory infections

This paper evaluates a novel fluorobenzothiazole inhibitor, RBx 10080758, showing potent in vitro and in vivo activity against drug-resistant Gram-positive bacteria by dual targeting Gyrase B and Topoisomerase IV.

Differential scanning fluorimetry as a measure of functionality of refolded anti-malarial antibody fragments

This study uses differential scanning fluorimetry to assess the functionality of refolded anti-malarial antibody fragments, finding that 4B7-Db retains activity while 1245-Db shows weak recognition.

Harmonin homology domain-mediated interaction of RTEL1 helicase with RPA and DNA provides mechanistic insight into its role in DNA repair

This study identifies a novel interaction between RTEL1 and RPA, showing their co-localization during DNA damage and revealing structural details of HHD2 binding to RPA and DNA.

Selection for greater dispersal in early life leads to increased rate of age-dependent decline in locomotor activity and shorter lifespan

This study shows that selecting for greater dispersal in Drosophila leads to faster age-related decline in locomotor activity and shorter lifespan.