Cleavage of the pseudoprotease iRhom2 by the signal peptidase complex reveals an ER-to-nucleus signalling pathway
I. Dulloo, M. Tellier, C. Levet, A. Chikh, B. Zhang, C. M. Webb, D. P. Kelsell, M. Freeman
The paper identifies a novel ER-to-nucleus signaling pathway mediated by iRhom2 cleavage by the signal peptidase complex, linking it to psoriasis and TOC.
bioRxiv · Nov 28, 2022 · PreprintCell Biology