M. Freeman

Eta-secretase-like processing of the amyloid precursor protein (APP) by RHBDL4

This study identifies RHBDL4 as an enzyme that processes APP similarly to {eta}-secretase, generating A{eta}-like fragments in the ER without requiring other proteases.

Cleavage of the pseudoprotease iRhom2 by the signal peptidase complex reveals an ER-to-nucleus signalling pathway

The paper identifies a novel ER-to-nucleus signaling pathway mediated by iRhom2 cleavage by the signal peptidase complex, linking it to psoriasis and TOC.

The HERV-K(HML-2) Transcriptome in Non-diseased Tissue

The paper characterizes HERV-K(HML-2) transcriptome expression in non-diseased tissues using GTEx RNA-seq data, finding widespread expression and subgroup-specific tissue biases.

An open-access volume electron microscopy atlas of whole cells and tissues

The paper presents a 3D electron microscopy atlas of whole cells and tissues with high resolution and large volume, enabling new biological insights.

A serotonergic axon-cilium synapse drives nuclear signaling to maintain chromatin accessibility

The paper identifies axo-ciliary synapses that mediate serotonin signaling to regulate chromatin accessibility in hippocampal neurons.

iRhom2 regulates ERBB signalling to promote KRAS-driven oncogenesis

This study shows that iRhom2 promotes KRAS-driven oncogenesis by enhancing ADAM17-dependent shedding of ERBB ligands through phosphorylation and 14-3-3 protein recruitment.

RHBDL4 protects against endoplasmic reticulum stress by regulating the morphology and distribution of ER sheets

This study identifies RHBDL4 as a regulator of ER morphology and distribution, showing its protective role against ER stress without requiring enzymatic activity.

Cap-dependent translation initiation monitored in living cells

The paper uses live-cell imaging to study the dynamics of translation initiation factors at the 5' cap, revealing their temporal regulation.

Conformational surveillance of Orai1 by a rhomboid intramembrane protease prevents inappropriate CRAC channel activation

The paper identifies RHBDL2 as a rhomboid protease that surveils and cleaves active Orai1 to prevent inappropriate CRAC channel activation, maintaining proper T cell signaling.

Correlative three-dimensional super-resolution and block face electron microscopy of whole vitreously frozen cells

This study develops a platform for 3D correlative cryogenic super-resolution and block-face EM of whole vitreously frozen cells, revealing new protein-ultrastructure relationships.

Spastin tethers lipid droplets to peroxisomes and directs fatty acid trafficking through ESCRT-III

This study identifies Spastin's role in tethering lipid droplets to peroxisomes and facilitating fatty acid trafficking via ESCRT-III proteins.

Quantitative Proteomic Analysis of Prostate Tissue Specimens Identifies Deregulated ProteinComplexes in Primary Prostate Cancer

This study identifies deregulated protein complexes in prostate cancer tissues using quantitative proteomics and reveals differences between low-grade and high-grade prostate cancer.

MeCP2-E1 isoform is a dynamically expressed, weakly DNA-bound protein with different protein and DNA interactions compared to MeCP2-E2

This study compares MeCP2-E1 and E2 isoforms, showing differences in DNA binding, protein interactions, and dynamic behavior, with implications for their functional roles in chromatin regulation.

FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex

This study identifies FRMD8 as a stabilizer of the iRhom2/ADAM17 complex, essential for ADAM17-mediated shedding of cytokines and growth factors.