Epithelial uptake of Aspergillus fumigatus drives efficient fungal clearance in vivo and is aberrant in Chronic Obstructive Pulmonary Disease (COPD)
M. Bertuzzi, G. J. Howell, D. D. Thomson, R. Fortune-Grant, A. Moeslinger, P. Dancer, N. Van Rhijn, N. Motsi, X. Du, A. Codling, R. Shah, M. Demirbag, E. Bignell
The paper shows that airway epithelial cells efficiently kill inhaled Aspergillus fumigatus spores in vivo, but this process is impaired in COPD.
bioRxiv · Feb 1, 2022Microbiology