M. Bertuzzi

Cryptococcus displays spore-specific invasion of alveolar epithelial cells

This study shows Cryptococcus spores invade alveolar epithelial cells in vitro and in vivo, suggesting these cells may serve as an intracellular niche for dissemination and latency.

Mgl2+ cDC2s coordinate fungal allergic airway type 2, but not type 17, inflammation.

The paper identifies Mgl2+ cDC2s as key drivers of type 2, but not type 17, fungal allergic airway inflammation in mice.

Mutual inhibition of airway epithelial responses supports viral and fungal co-pathogenesis during coinfection

This study shows that viral and fungal infections inhibit each other's clearance by airway epithelial cells during coinfection, promoting disease severity.

Epithelial uptake of Aspergillus fumigatus drives efficient fungal clearance in vivo and is aberrant in Chronic Obstructive Pulmonary Disease (COPD)

The paper shows that airway epithelial cells efficiently kill inhaled Aspergillus fumigatus spores in vivo, but this process is impaired in COPD.

Aspergillus fumigatus drives tissue damage via iterative assaults upon mucosal integrity and immune homeostasis

This paper investigates how Aspergillus fumigatus causes lung damage by analyzing host responses to different fungal morphotypes and secreted products in cultured cells and a mouse model.