X. Du

Generation of High-fidelity Blastocyst-like Structures from Porcine Expanded Pluripotent stem cell via Chemically inducing cell plasticity

This study generates blastocyst-like structures from porcine pluripotent stem cells using chemical induction, achieving up to 80% efficiency and mimicking natural blastocysts in morphology and transcriptome.

FLASH radiotherapy using high-energy X-rays: validation of the FLASH effect triggered by a compact single high-energy X-ray source device

This study validates the FLASH effect using a compact high-energy X-ray source in mice, showing protective effects on normal tissues but no significant tumor response differences between FLASH and conventional radiotherapy.

StomaVision: stomatal trait analysis through deep learning

StomaVision automates stomatal trait analysis from micrographs, revealing physiological responses to heat stress across plant species.

A method for recognizing motor imagery EEG signals based on high-quality lead selection

The paper proposes a channel selection strategy for motor imagery EEG signals using brain function networks, reducing channel count while improving recognition accuracy.

Matrimeres are systemic nanoscale mediators of tissue integrity and function

The paper identifies matrimeres as nanoscale mediators of tissue integrity, showing they can restore vascular integrity after injury and are reconstituted from fibronectin, DNA, and acidic conditions.

A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity

This study shows that a PTP1B/PTPN2 inhibitor enhances T cell anti-tumor immunity in mice, improves tumor response to PD1 therapy, and avoids immune-related toxicities.

Reprogramming of lipid secretome in senescent synovial fibroblasts ameliorate osteoarthritis development

This study identifies RCAN1+IL1+ senescent synovial fibroblasts as drivers of osteoarthritis by secreting saturated fatty acids, and shows that targeting RCAN1 reduces OA progression in mice.

3D-Printed LEGO(R)-inspired Titanium Scaffolds for Patient-Specific Regenerative Medicine

This paper presents a 3D-printed titanium scaffold that can be manually assembled to fit patient-specific defects, improving mechanical properties and cellular activity through porous structures and surface treatment.

CTLA-4 antibody-drug conjugate reveals autologous destruction of B-lymphocytes associated with regulatory T cell impairment

The paper shows that anti-CTLA-4 ADC treatment causes B cell depletion via T cell hyper-proliferation and regulatory T cell impairment in CTLA-4 knock-in mice.

Modeling epithelial tissue and cell deformation dynamics using a viscoelastic slab sculpted by surface forces

The paper develops a 3D viscoelastic model of epithelial tissue to study how surface forces influence cell deformation and dynamics, with applications to Drosophila embryogenesis.

Sketch the Organoids from Birth to Death Development of an Intelligent OrgaTracker System for Multi-Dimensional Organoid Analysis and Recreation

This paper introduces OrgaTracker, a system using deep learning to track and analyze organoid growth, and generates artificial organoids from sketches.

Tunable image-mapping optical coherence tomography

This paper introduces TIM-OCT, a tunable imaging technique that provides high resolution in either lateral or axial dimensions or across all dimensions, and demonstrates its application on biological samples.

Molecular mechanism of substrate recognition by folate transporter SLC19A1

This study determines the cryo-EM structure of SLC19A1 and identifies key residues and coupled substrates for folate recognition.

ATG5- and ATG7-mediated autophagy regulates pollen tube guidance and male fertility in Arabidopsis thaliana

A Genome-scale Screen Reveals ANTXR1, Heparan Sulfate and Neu5Gc as Host Factors mediating Seneca Valley virus Entry into Porcine Cells

This study identifies ANTXR1, heparan sulfate, and Neu5Gc as host factors required for SVV entry into porcine cells using CRISPR screening.

Label-Free Hyperspectral Imaging and Deep-Learning Prediction of Retinal Amyloid β-Protein and Phosphorylated Tau

This paper develops a label-free hyperspectral imaging method combined with deep learning to detect and predict retinal amyloid β-protein and phosphorylated tau in Alzheimer's disease.

E. coli can eat DNA as excellent nitrogen source to grow quickly

This study shows E. coli can use DNA as a nitrogen source for growth, outperforming Bifidobacterium bifidum, and ingests long DNA directly without altering its length.

Epithelial uptake of Aspergillus fumigatus drives efficient fungal clearance in vivo and is aberrant in Chronic Obstructive Pulmonary Disease (COPD)

The paper shows that airway epithelial cells efficiently kill inhaled Aspergillus fumigatus spores in vivo, but this process is impaired in COPD.

Antibodies to ILT3 abrogate myeloid immunosuppression and enable tumor killing

This study shows anti-ILT3 antibodies block myeloid immunosuppression and enhance tumor killing in solid tumors.

Lateral plate mesoderm cell-based organoid system for NK cell regeneration from human pluripotent stem cells

This study develops an organoid-based method to generate large quantities of NK cells from human pluripotent stem cells without feeder cells, achieving efficient and scalable iNK cell production.

PTP1B is an intracellular checkpoint that limits T cell and CAR T cell anti-tumor immunity

This study identifies PTP1B as an intracellular checkpoint that limits T cell and CAR T cell anti-tumor immunity, showing its deletion or inhibition enhances tumor suppression.

Soil inoculum identity and rate jointly steer microbiomes and plant communities in the field

This study shows that soil inoculum origin and amount affect microbiome and plant community development in degraded grasslands over three years.

Knockout of murine Lyplal1 confers sex-specific protection against diet-induced obesity

This study shows that knocking out Lyplal1 in mice leads to sex-specific protection against diet-induced obesity, mirroring human genetic findings.

Perturbation of transmembrane 6 superfamily member 2 expression alters lipid metabolism in a human liver cell line

This study shows that TM6SF2 overexpression or loss-of-function alters lipid metabolism in human liver cells by changing lipid species composition and gene expression.

Bistable host-pathogen interaction explains varied infection outcomes

The paper develops a mathematical model to show that host-pathogen interactions can lead to bistable infection outcomes, where pathogen load either proliferates or is eliminated.

Autophagy Induced by Palmitic Acid: a Brake in NAFLD Neutrophils

This paper shows that palmitic acid induces autophagy in NAFLD neutrophils, leading to granule degradation and reduced adhesion, impairing neutrophil function.

Untangling the cell immune response dynamic for severe and critical cases of SARS-CoV-2 infection

This study uses mathematical models to analyze immune response dynamics in severe and critical SARS-CoV-2 cases, finding that rapid CD8+ T cell proliferation is critical for disease severity.

A H3K9me2-Binding Protein AGDP3 Limits DNA Methylation and Transcriptional Gene Silencing in Arabidopsis

This study identifies AGDP3 as a protein that binds H3K9me2 and facilitates ROS1-mediated DNA demethylation in Arabidopsis, revealing a mechanism linking histone modification to gene regulation.

Suppression of Plasmodium MIF-CD74 Signaling Protects Against Severe Malaria

This study shows that blocking Plasmodium MIF-CD74 signaling protects against experimental cerebral malaria by preventing antigen presentation to CD8+ T cells.

Liver X Receptor; Controls Hepatic Stellate Cell Activation via Hedgehog Signaling

This study shows that LXRβ suppresses hepatic stellate cell activation via inhibition of Hedgehog signaling, offering a potential therapeutic target for liver fibrosis without causing liver steatosis.