Derlin rhomboid pseudoproteases employ substrate engagement and lipid distortion function for retrotranslocation of ER multi-spanning membrane substrates
A. Nejatfard, N. Wauer, S. Bhaduri, A. Conn, S. Gourkanti, N. Singh, T. Kuo, R. R. Kandel, R. E. Amaro, S. E. Neal
This study identifies the mechanism by which derlin rhomboid pseudoproteases facilitate retrotranslocation of ER membrane substrates through substrate engagement and lipid thinning.
bioRxiv · Jun 15, 2021Cell Biology