T. Kuo

Formamide denaturation of double-stranded DNA for fluorescence in situ hybridization (FISH) distorts nanoscale chromatin structure

This study shows that formamide in 3D FISH distorts nanoscale chromatin structure, while alternative methods like RASER-FISH and CRISPR-Sirius have minimal impact.

Cyb5r3-based mechanism and reversal of secondary failure to sulfonylurea

This study identifies Cyb5r3 downregulation as a mechanism of sulfonylurea failure and shows that a Cyb5r3 activator can reverse this failure in an animal model.

Triple Notch/Tgfβ/FoxO1 blockade converts multiple intestinal sub-lineages into β-like cells and lowers glycemia in diabetic animals

Derlin Dfm1 Employs a Chaperone Function to Resolve Misfolded Membrane Protein Stress

The paper identifies a chaperone function of Dfm1 in resolving misfolded membrane protein stress in yeast, independent of Cdc48 and distinct from its previously known role in protein dislocation.

Derlin rhomboid pseudoproteases employ substrate engagement and lipid distortion function for retrotranslocation of ER multi-spanning membrane substrates

This study identifies the mechanism by which derlin rhomboid pseudoproteases facilitate retrotranslocation of ER membrane substrates through substrate engagement and lipid thinning.

Systemic benefits of Gc inhibition to preserve insulin sensitivity

This study shows that inhibiting Gc improves insulin sensitivity and beta-cell function in mice, preventing weight gain and hyperglycemia on a high-fat diet.

Antagonistic epistasis of Hnf4a and FoxO1 networks through enhancer interactionsin beta-cell function

The paper investigates the antagonistic epistasis between Hnf4a and FoxO1 networks in beta-cell function through enhancer interactions and gene expression analysis.