Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells
N. Vilaplana-Lopera, R. Almaghrabi, G. Papatzikas, V. Cuminetti, E. Gonzalez, M. Jeeves, A. Cunningham, A. Erdem, F. Schnuetgen, M. Raghavan, S. Potluri, J.-B. Cazier, J. J. Schuringa, M. A. Reed, L. Arranz, , P. Garcia
The paper identifies a metabolic crosstalk between AML and stromal cells where AML cells induce stromal cells to secrete acetate for their own energy needs.
bioRxiv · Jan 21, 2021Cell Biology