P. Garcia

Integrating in silico predictions with an engineered tissue assay identifies Perlecan as an age-perturbed re-quiescence cue for muscle stem cells

The paper identifies Perlecan as a factor that influences muscle stem cell re-quiescence, showing its age-related changes and therapeutic potential.

Rgf1 GEF activity toward Rho1 defines a new actin-dependent signal to determine growth sites independently of microtubules and Tea1

The paper shows Rgf1-Rho1 activity establishes growth sites via actin polarization, independent of microtubules and Tea1-Tea4.

Repression of pattern-triggered immune responses by hypoxia in Arabidopsis

This study shows hypoxia represses key aspects of plant immunity by interfering with transcriptional programs and immune signaling pathways.

A heterozygous CEBPA mutation disrupting the bZIP domain causes MDS disease progression

This study shows a heterozygous CEBPA mutation in the bZIP domain causes MDS progression by altering chromatin structure and clonal composition, using patient-derived iPSCs.

Setdb1 safeguards genome integrity in muscle stem cells to allow for regenerative myogenesis and inflammation

This study shows that Setdb1 in muscle stem cells prevents endogenous retrovirus activation and maintains genome stability, which is essential for muscle regeneration and inflammation control.

Heavy Metal Pollution From a Major Earthquake and Tsunami in Chile Is Associated With Geographic Divergence of Clinical Isolates of Methicillin-Resistant Staphylococcus aureus in Latin America

This study links heavy-metal pollution from a Chilean earthquake and tsunami to the geographic spread of MRSA clones in Latin America.

Dynamics of the MRSA Population in A Chilean Hospital: A Phylogenomic Analysis (2000-2016)

This study analyzes MRSA clonal dynamics in a Chilean hospital from 2000-2016, finding increased diversity and the emergence of new clones replacing the dominant ChC clone.

Discordant population structure inferred from male- and female-type mtDNAs from Macoma balthica, a bivalve species characterized by doubly uniparental inheritance of mitochondria

The paper compares genetic structure of male- and female-type mtDNA in Macoma balthica to assess phylogeographic differences and mito-nuclear interactions.

Sequence-function relationships in phage-encoded bacterial cell wall lytic enzymes and their implications for phage-derived products design

This study analyzes phage-encoded lysin sequences to identify structural and physicochemical features associated with their function against Gram-negative bacteria, revealing genetic specialization and providing a database for further research.

Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells

The paper identifies a metabolic crosstalk between AML and stromal cells where AML cells induce stromal cells to secrete acetate for their own energy needs.

MYBL2 regulates ATM to control replication initiation and prevent replication stress in pluripotent stem cells

This study shows MYBL2 activates ATM to suppress replication stress in ESCs, with loss of MYBL2 or ATM causing replication fork slowing and increased origin firing.

Ablation of MYB-dependent leukaemia phenotype in MLL-driven AML correlates with increased expression of MAFB.

The paper shows that MYB ablation in MLL-driven AML increases MAFB expression, while this effect is absent in AML with complex karyotypes.

The common analgesic paracetamol enhances the anti-tumour activity of decitabine through exacerbation of oxidative stress

This study shows that paracetamol enhances decitabine's anti-tumour effects by increasing oxidative stress without worsening DNA damage.

The BUBR1 pseudokinase domain promotes efficient kinetochore PP2A-B56 recruitment to regulate spindle checkpoint silencing and chromosome alignment

This study shows the BUBR1 pseudokinase domain enhances PP2A-B56 recruitment to kinetochores, ensuring proper checkpoint silencing and chromosome alignment by modulating phosphorylation.