A. Robinson

Polycaprolactone-based shape memory foams as self-fitting vaginal stents

This paper develops a self-fitting vaginal stent using shape-memory polymer foams that expand at body temperature to prevent vaginal stenosis, demonstrating effective shape recovery and retention in a simulated model.

Enterobactin and Salmochelin S4 inhibit the growth of Staphylococcus aureus

This study shows that enterobactin and salmochelin S4 inhibit Staphylococcus aureus and Enterococcus growth, including resistant strains, with potential for new antimicrobial strategies.

Forecasting trade and biosecurity risk under climate change

This paper develops a model framework to forecast climate-induced changes in trade patterns and biosecurity risk by integrating economic and ecological sub-models.

Critical analysis of polycyclic tetramate macrolactam biosynthetic cluster phylogeny and functional diversity

This study analyzes PTM biosynthetic clusters to uncover their phylogenetic diversity and functional complexity, revealing gaps in bioinformatics predictions and highlighting challenges in genomic discovery.

Sequential gentle hydration increases encapsulation in model protocells

This study improves encapsulation efficiency in gentle hydration of lipid vesicles by sequential hydration, showing increased cargo encapsulation and fatty acid concentration.

The effects of resistance training on denervated myofibers, senescent cells, and associated protein markers in middle-aged adults

This study examines how resistance training affects denervated myofibers, senescent cells, and related proteins in middle-aged adults, finding increased muscle-nerve communication proteins but no significant changes in senescent cell content or SASP proteins.

Hydrogel-Polyurethane Fiber Composites With Enhanced Microarchitectural Control For Heart Valve Replacement

This paper develops a hydrogel-polyurethane fiber composite for heart valve replacement, showing reduced platelet and bacterial attachment and calcification compared to pericardium, with promising hemodynamic performance.

Spatiotemporal dynamics of single-stranded DNA intermediates in Escherichia coli

The paper uses fluorescence microscopy to study the spatiotemporal dynamics of single-stranded DNA in live E. coli cells, revealing patterns associated with DNA repair and replication.

Validation and Establishment of a SARS-CoV-2 Lentivirus Surrogate Neutralization Assay as a pre-screening tool for the Plaque Reduction Neutralization Test

RET Signaling Persists in the Adult Intestine and Stimulates Motility by Limiting PYY Release from Enteroendocrine Cells

This study shows RET signaling in the adult intestine limits PYY release from L-cells, which is necessary for normal gut motility in male mice.

Fast Evolution of SOS-Independent Multi-Drug Resistance in Bacteria

This study shows that Escherichia coli lacking RecA rapidly develops beta-lactam resistance through an SOS-independent mechanism involving oxidative stress and DNA repair defects.

Defects in DNA double-strand break repair re-sensitise antibiotic-resistant Escherichia coli tomultiple bactericidal antibiotics

The paper identifies DNA double-strand break repair defects in antibiotic-resistant E. coli as a strategy to re-sensitize bacteria to multiple bactericidal antibiotics.

Systemic influences of mammary cancer on monocytes in mice

This study shows that mammary cancer in mice increases circulating and splenic monocytes without altering their ratios or half-lives, but changes their transcriptome, particularly in the bone marrow and blood, with differences from human breast cancer.

ARID1A-mutant and deficient bladder cancer is sensitive to EZH2 pharmacologic inhibition

This study shows that ARID1A-deficient bladder cancer cells are sensitive to EZH2 inhibition, suggesting a therapeutic strategy for patients with ARID1A mutations.

The Pancreatic Tumor Microenvironment Compensates for Loss of GOT2

This study shows that the pancreatic tumor microenvironment compensates for loss of GOT2 by providing pyruvate, maintaining redox homeostasis and tumor growth in vivo.

Iron is a ligand of SecA-like metal-binding domains in vivo

This study identifies iron as a ligand for SecA-like metal-binding domains in E. coli, showing that these domains bind iron preferentially and that azide disrupts this interaction.

Responses of the putative trachoma vector, Musca sorbens, to volatile semiochemicals from human faeces

This study identifies volatile semiochemicals in human faeces that attract Musca sorbens, a trachoma vector, suggesting potential for developing chemical lures to control the species.

Modulation of DNA polymerase IV activity by UmuD and RecA* observed by single-molecule time-lapse microscopy

The paper shows UmuD and RecA modulate DNA polymerase IV binding to DNA substrates, with UmuD inhibiting and RecA promoting association, particularly in DNA-damaged cells.

Recycling of single-stranded DNA-binding protein by the bacterial replisome.

This study visualizes how the E. coli replisome recruits and recycles single-stranded DNA-binding protein using two mechanisms, showing their physiological relevance.

Genetic screen suggests an alternative mechanism for azide-mediated inhibition of SecA

The paper uses a genetic screen to show azide inhibits SecA by causing it to backtrack in its ATPase cycle, disrupting membrane and metal cofactor binding.

The essential genome of Escherichia coli K-12

This study benchmarks TraDIS against single gene deletion libraries to identify essential genes in E. coli, revealing new essential genes and correcting previous designations.