E. Gonzalez

Untargeted metabolomics reveals anion and organ-specific biochemistry of salinity tolerance in willow

This study uses untargeted metabolomics to analyze salinity tolerance in willows, revealing organ-specific and ion-specific metabolic responses to NaCl and Na2SO4.

Cell of origin alters myeloid-mediated immunosuppression in lung adenocarcinoma

This study shows that the cell of origin in lung adenocarcinoma affects the immunosuppressive state of the tumor microenvironment, with AT1-derived tumors showing an anti-tumor immune profile and AT2-derived tumors showing immunosuppressive features.

Mimicking the breast metastatic microenvironment: characterization of a novel syngeneic model of HER2+ breast cancer

The paper characterizes a novel syngeneic murine breast cancer model (NT2.5-LM) that exhibits rapid and widespread metastases, enabling study of metastatic progression and therapeutic responses.

Oblique Line Scan Illumination Enables Expansive, Accurate and Sensitive Single Protein Measurements in Solution and in Living Cells

This paper introduces Oblique Line Scan (OLS) illumination to enhance single-molecule tracking in living cells and solution, enabling high-throughput and sensitive protein dynamics measurements.

Fertilisation of agricultural soils with municipal biosoilds: Part 2- Site properties, environmental factors, and crop identify influence soil bacterial communities more than municipal biosolid application

This study investigates the impact of municipal biosolids on soil bacterial communities in agricultural settings and finds that soil properties, crop type, and environmental factors have a greater influence than biosolids application.

UPL3 Promotes BZR1 Degradation, Growth Arrest, and Seedling Survival under Starvation Stress in Arabidopsis

This study identifies UPL3 as an E3 ubiquitin ligase that promotes BZR1 degradation under sugar starvation, leading to growth arrest and improved seedling survival in Arabidopsis.

A high-throughput platform for single-molecule tracking identifies drug interaction and cellular mechanisms

This paper introduces a high-throughput single-molecule tracking platform to study protein dynamics and drug interactions, identifying novel mechanisms and therapeutics.

A multiplexed, confinable CRISPR/Cas9 gene drive propagates in caged Aedes aegypti populations

The paper tests a CRISPR/Cas9 gene drive in caged Aedes aegypti populations, showing it increases from 50% to 89% carrier frequency despite fitness costs.

Colloidal physics modeling reveals how per-ribosome productivity increases with growth rate in E. coli

The paper models E. coli cytoplasm to show that physical crowding and transport improve ribosome productivity with growth rate.

Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells

The paper identifies a metabolic crosstalk between AML and stromal cells where AML cells induce stromal cells to secrete acetate for their own energy needs.

Identification of trans-AT polyketide clusters in two marine bacteria reveals cryptic similarities between distinct symbiosis factors

This paper identifies trans-AT polyketide gene clusters in two marine bacteria, revealing evolutionary relationships between sesbanimides, glutaramides, and pederin-like pathways.

MYBL2 regulates ATM to control replication initiation and prevent replication stress in pluripotent stem cells

This study shows MYBL2 activates ATM to suppress replication stress in ESCs, with loss of MYBL2 or ATM causing replication fork slowing and increased origin firing.

Exposure to parasitic protists and helminths changes the intestinal community structure of bacterial microbiota but not of eukaryotes in a cohort of mother-child binomial from a semi-rural setting in Mexico

This study examines how exposure to intestinal parasites affects bacterial and eukaryotic microbiota in a mother-child cohort in Mexico, finding significant bacterial community changes but not eukaryotic ones.