Traumatic Brain Injury Impairs Systemic Vascular Function Through Altered Lipid Metabolism and Disruption of Inward-Rectifier Potassium (Kir2.1) Channels
A. M. Sackheim, N. Villalba, M. Sancho, O. F. Harraz, A. D. Bonev, A. D'Alessandro, T. Nemkov, M. T. Nelson, K. Freeman
This study shows traumatic brain injury impairs vascular function by reducing Kir2.1 channel activity through PIP2 depletion caused by increased H2O2 and PLA2 activity.
bioRxiv · Jan 15, 2021Physiology