Author

K. Freeman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1 Immunology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. M. Sackheim· 2 shared B. A. Bouchard· 2 shared D. Majumdar· 2 shared M. T. Nelson· 2 shared N. Villalba· 2 shared A. D. Bonev· 1 shared A. D'Alessandro· 1 shared A. Davidoff· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersImmunology

A. M. Sackheim

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing is associated with therapeutic response to splicing inhibitor

J. YANG, C. M. Jablonowski, W. Quarni, S. Singh, H. Tan, D. H. Bostanthirige, H. Jin, J. Fang, T.-C. Chang, D. Finkelstein, J.-H. Cho, D. Hu, V. Pagala, S. M. Sakurada, S. M. Pruett-Miller, , G. Wu

This study shows JMJD6 links pre-mRNA splicing and metabolism in MYC-driven cancers, and its inhibition enhances therapeutic response to splicing inhibitors.

bioRxiv · Jun 26, 2023Cancer Biology

A structural dendrogram of the actinobacteriophage major capsid proteins provides important structural insights into the evolution of capsid stability

J. M. Podgorski, K. Freeman, S. Gosselin, A. Huet, J. F. Conway, M. Bird, J. Grecco, S. Patel, D. Jacobs-Sera, G. Hatfull, J. P. Gogarten, J. Ravantti, S. J. White

The paper constructs a structural dendrogram of actinobacteriophage major capsid proteins to explore the evolution of capsid stability using cryo-EM, phylogenetic analysis, and AlphaFold predictions.

bioRxiv · Sep 9, 2022Biochemistry

The polyanionic drug suramin neutralizes histones and prevents endotheliopathy

N. Villalba, A. M. Sackheim, M. A. Lawson, L. Haines, Y. L. Chen, S. K. Sonkusare, Y.-T. Ma, J. Li, D. Majumdar, B. A. Bouchard, J. E. Boyson, M. E. Poynter, M. T. Nelson, K. Freeman

This paper shows suramin neutralizes histones, preventing endothelial damage and improving vascular function in inflammatory conditions.

bioRxiv · Dec 9, 2021Immunology

Increased Histone-DNA Complexes and Endothelial-Dependent Thrombin Generation in Severe COVID-19

B. A. Bouchard, C. Colovos, M. Lawson, A. Sackhiem, K. J. Mould, W. J. Janssen, M. J. Cohen, D. Majumdar, K. Freeman

This study finds elevated histone-DNA complexes and altered thrombin generation in severe COVID-19 patients, with endothelial-dependent thrombin generation contributing to coagulopathy.

bioRxiv · Jul 3, 2021Biochemistry

Traumatic Brain Injury Impairs Systemic Vascular Function Through Altered Lipid Metabolism and Disruption of Inward-Rectifier Potassium (Kir2.1) Channels

A. M. Sackheim, N. Villalba, M. Sancho, O. F. Harraz, A. D. Bonev, A. D'Alessandro, T. Nemkov, M. T. Nelson, K. Freeman

This study shows traumatic brain injury impairs vascular function by reducing Kir2.1 channel activity through PIP2 depletion caused by increased H2O2 and PLA2 activity.

bioRxiv · Jan 15, 2021Physiology