A. D. Gruber

The paper compares single-cell RNA-seq data from hamster and human COVID-19 samples to identify a shared inflammatory axis and a neutrophil-endothelial program associated with severe disease.

This study shows that Ganetespib, an HSP90 inhibitor, reduces SARS-CoV-2 replication and inflammation in vitro and improves clinical outcomes in infected Syrian golden hamsters.

This study compares immune responses and efficacy of different SARS-CoV-2 vaccines in hamsters, finding that a live-attenuated vaccine provides superior protection against variants.

The paper identifies PIRAT, a lncRNA regulating monocyte immunity in COVID-19 via PU.1 feedback, and shows its role in alarmin production.

This paper describes ensovibep, a trispecific DARPin that inhibits SARS-CoV-2 variants by targeting the spike protein, showing potent antiviral activity and protection in animal models.

The paper integrates longitudinal omics data from Syrian hamsters with human data to understand immune responses to SARS-CoV-2, identifying key cellular and molecular mechanisms.

This study identifies a potent SARS-CoV-2 neutralizing antibody that protects hamsters from infection and lung damage.

This study compares SARS-CoV-2 infection progression in young and aged Syrian hamsters, finding age-related differences in weight loss, immune response, and lung recovery.