M. Landthaler

The paper compares single-cell RNA-seq data from hamster and human COVID-19 samples to identify a shared inflammatory axis and a neutrophil-endothelial program associated with severe disease.

This study shows that Ganetespib, an HSP90 inhibitor, reduces SARS-CoV-2 replication and inflammation in vitro and improves clinical outcomes in infected Syrian golden hamsters.

A single dose of a recombinant murine CMV vaccine expressing SARS-CoV-2 spike protein provides long-lasting immunity against multiple variants in mice.

This study compares immune responses and efficacy of different SARS-CoV-2 vaccines in hamsters, finding that a live-attenuated vaccine provides superior protection against variants.

This study compares TH1 and TH2-biased vaccines in Syrian hamsters, showing that TH1 vaccines prevent severe disease without inducing VAERD, while TH2 vaccines cause VAERD through eosinophil recruitment and TH2 cytokine upregulation.

The paper quantifies mRNA and lncRNA transfer between human and mouse cells in co-culture, showing non-selective transfer and correlation with donor gene expression.

This paper engineers, decodes, and characterizes chimpanzee cytomegalovirus (CCMV) to explore its potential as a model for human CMV, identifying novel genes, regulatory elements, and functional roles.

This study shows herpesviruses induce DUX4 expression, which drives viral gene expression by mimicking embryonic genome activation.

The paper integrates longitudinal omics data from Syrian hamsters with human data to understand immune responses to SARS-CoV-2, identifying key cellular and molecular mechanisms.

The paper uses single-cell RNA-seq to analyze antiviral responses and viral antagonism in Chikungunya virus-infected synovial fibroblasts, identifying interferon-stimulated genes and immune-related pathways.

This study shows that type I interferons can enhance NK cell killing of HIV-1-reactivating T-cells despite HDACi-induced immune dysregulation, suggesting a potential strategy to improve shock-and-kill approaches.

The paper identifies a cancer-specific rRNA modification loss in multiple cancers, linking it to oncogenic translational signatures and potential therapeutic targets.

The paper identifies mitogen-activated protein kinase activity as a driver of cell trajectories in colorectal cancer using single-cell transcriptomics and organoid models.

This study decodes the complete HSV-1 transcriptome and translatome during lytic infection, identifying novel transcripts, ORFs, and regulatory elements.