J. Trimpert

NSP4 mutation T492I drives rapid evolution of SARS-CoV-2 toward Omicron

This study shows that the NSP4 T492I mutation increases SARS-CoV-2 mutation rates and accelerates the emergence of Omicron-like mutations.

Neural Network-Assisted Humanization of COVID-19 Hamster scRNAseq Data Reveals Matching Severity States in Human Disease

This paper uses neural networks to match disease states between human and hamster COVID-19 scRNAseq data, finding similar cellular responses in specific cell types across species.

Single-cell-resolved interspecies comparison identifies a shared inflammatory axis and a dominant neutrophil-endothelial program in severe COVID-19

The paper compares single-cell RNA-seq data from hamster and human COVID-19 samples to identify a shared inflammatory axis and a neutrophil-endothelial program associated with severe disease.

Antigenic cartography using variant-specific hamster sera reveals substantial antigenic variation among Omicron subvariants

The paper uses hamster sera from variant-specific infections to map antigenic differences among SARS-CoV-2 variants, revealing significant antigenic variation among Omicron subvariants.

T492I mutation alters SARS-CoV-2 properties via modulating viral non-structural proteins

The paper investigates the T492I mutation in SARS-CoV-2 NSP4, showing it increases transmissibility, replication, and antibody evasion by enhancing NSP5 cleavage efficiency and reducing viral RNA-associated chemokines.

Tissue protective role of Ganetespib in SARS-CoV-2-infected Syrian golden hamsters

This study shows that Ganetespib, an HSP90 inhibitor, reduces SARS-CoV-2 replication and inflammation in vitro and improves clinical outcomes in infected Syrian golden hamsters.

A live attenuated vaccine confers superior mucosal and systemic immunity to SARS-CoV-2 variants

This study compares immune responses and efficacy of different SARS-CoV-2 vaccines in hamsters, finding that a live-attenuated vaccine provides superior protection against variants.

Nucleocapsid 203 mutations enhance SARS-CoV-2 immune evasion

This study shows that the nucleocapsid 203 mutation, combined with spike L452R, enhances SARS-CoV-2 immune evasion and fitness, contributing to the dominance of variants like Delta and Omicron.

Unconventional secretion of unglycosylated ORF8 is critical for the cytokine storm during SARS-CoV-2 infection

This study identifies unconventional secretion of unglycosylated ORF8 as critical for inducing cytokine storms during SARS-CoV-2 infection by interacting with IL17RA on macrophages.

Post-entry, spike-dependent replication advantage of B.1.1.7 and B.1.617.2 over B.1 SARS-CoV-2 in an ACE2-deficient human lung cell line

The paper shows that B.1.1.7 and B.1.617.2 SARS-CoV-2 variants have a replication advantage over B.1 in ACE2-deficient lung cells, suggesting reliance on alternative cellular factors.

In vitro efficacy of Artemisia extracts against SARS-CoV-2

This study evaluates the in vitro antiviral efficacy of Artemisia extracts and a herbal drink against SARS-CoV-2 and FCoV, showing inhibition at non-toxic concentrations.

Longitudinal omics in Syrian hamsters integrated with human data unravel complexity of moderate immune responses to SARS-CoV-2

The paper integrates longitudinal omics data from Syrian hamsters with human data to understand immune responses to SARS-CoV-2, identifying key cellular and molecular mechanisms.

A SARS-CoV-2 neutralizing antibody selected from COVID-19 patients by phage display is binding to the ACE2-RBD interface and is tolerant to most known recently emerging RBD mutations

The paper describes the selection of a SARS-CoV-2 neutralizing antibody from COVID-19 patients using phage display, showing it binds the ACE2-RBD interface and remains effective against emerging RBD mutations.

In vitro efficacy of Artemisinin-based treatments against SARS-CoV-2

This study evaluates the in vitro antiviral efficacy of Artemisia annua extracts and artemisinin derivatives against SARS-CoV-2, finding artesunate to be the most potent.

Multi-species ELISA for the detection of antibodies against SARS-CoV-2 in animals

The paper develops a multi-species ELISA to detect SARS-CoV-2 antibodies in animals, achieving 100% specificity and 98.31% sensitivity across multiple species.

A SARS-CoV-2 neutralizing antibody protects from lung pathology in a COVID-19 hamster model

This study identifies a potent SARS-CoV-2 neutralizing antibody that protects hamsters from infection and lung damage.

Age-dependent progression of SARS-CoV-2 infection in Syrian hamsters

This study compares SARS-CoV-2 infection progression in young and aged Syrian hamsters, finding age-related differences in weight loss, immune response, and lung recovery.

ACE2-Variants Indicate Potential SARS-CoV-2-Susceptibility in Animals: An Extensive Molecular Dynamics Study

The paper uses molecular dynamics simulations to analyze SARS-CoV-2 ACE2 variants and predicts susceptibility in red squirrels and specific mutations in dogs, rats, and mice.