Targeting H3K4 methylation as a novel therapeutic strategy against tumor infiltration and nuclear changes of acute lymphoblastic leukemia cells.
R. Gonzalez-Novo, A. De Lope, A. Gonzalez-Murillo, E. Madrazo, D. Acitores, M. Garcia de Lacoba, M. Ramirez, J. Redondo-Munoz
This study shows that targeting H3K4 methylation via WDR5 inhibition reduces leukemia cell invasion in vitro and tissue infiltration in vivo, revealing a novel therapeutic strategy for acute lymphoblastic leukemia.
bioRxiv · Jun 16, 2022 · PreprintCancer Biology