J. Redondo-Munoz

This study shows that PRLs regulate F-actin dynamics during T cell activation by interacting with WDR1, affecting IS formation and cytokine production.

The paper shows that 3D environments cause persistent nuclear changes, including lamin B1 distribution and mechanical behavior, affecting cell survival and migration.

The paper shows that persistent confined migration causes permanent nuclear and functional changes in cells, including lamin B1 redistribution and altered DNA repair.

This study shows that targeting H3K4 methylation via WDR5 inhibition reduces leukemia cell invasion in vitro and tissue infiltration in vivo, revealing a novel therapeutic strategy for acute lymphoblastic leukemia.