Diet-induced obesity results in endothelial cell desensitization to VEGF-A and permanent islet vascular dysfunction
Y. Xiong, A. Dicker, M. Visa, E. Ilegems, P.-O. Berggren
This study shows that diet-induced obesity causes permanent vascular dysfunction in pancreatic islets by desensitizing endothelial cells to VEGF-A, impairing glucose homeostasis.
bioRxiv · Nov 6, 2023 · PreprintPhysiology