H. Lickert

Resolving human α versus β cell fate allocation for the generation of stem cell-derived islets

The paper investigates human α and β cell fate allocation in stem cell-derived islets, revealing a distinct regulatory mechanism compared to mice and identifying pharmacological strategies to enhance cell fate commitment.

Chronic intermittent fasting impairs β-cell maturation and function in adolescent mice

This study shows chronic intermittent fasting impairs β-cell maturation and function in adolescent mice, but not in adults, with similar patterns observed in human type 1 diabetes.

Pantothenate Kinase 4 controls efficient skeletal muscle energy substrate metabolism via acetyl-CoA

This study identifies PanK4 as a regulator of skeletal muscle energy metabolism, showing its role in acetyl-CoA regulation and metabolic flexibility.

Multi-omics and 3D-imaging reveal bone heterogeneity and unique calvaria cells in neuroinflammation

The paper uses multi-omics and 3D-imaging to show that calvaria bone marrow has a distinct molecular profile and contributes to neuroinflammation.

Sequential in vivo labeling of insulin secretory granule pools in INS-SNAP transgenic pigs

This study develops a transgenic pig model with SNAP-tagged insulin to investigate in vivo insulin secretory granule dynamics and turnover.

A strategy to address dissociation-induced compositional and transcriptional bias for single-cell analysis of the human mammary gland

The paper presents a strategy to minimize dissociation-induced biases in single-cell analysis of human mammary glands by comparing different dissociation methods using single-cell RNA sequencing and flow cytometry.

Identification and characterization of distinct murine brown adipocyte lineages

The paper identifies and characterizes distinct murine brown adipocyte lineages using single-cell RNA sequencing and functional analysis.

Anatomical and cellular heterogeneity in the mouse oviduct-- its potential roles in reproduction and preimplantation development

This study examines the anatomical and cellular structure of the mouse oviduct, identifying new features and roles in reproduction and preimplantation development.

Islet vascularization is regulated by primary endothelial cilia via VEGF-A dependent signaling

This study shows that primary endothelial cilia regulate islet vascularization and vascular barrier function through VEGF-A/VEGFR2 signaling, with impaired vascularization observed in Bbs4-/- mice.