TKI Type Switching Overcomes ROS1 L2086F in ROS1 Fusion-Positive Cancers
R. Thawani, M. Repetto, C. Keddy, K. Nicholson, K. Jones, K. Nusser, C. Z. Beach, G. Harada, A. Drilon, M. A. Davare
This study shows that type II TKIs cabozantinib and merestinib, and type I FLT3 inhibitor gilteritinib, inhibit ROS1 L2086F mutant kinase, overcoming resistance to type I TKIs in ROS1 fusion-positive cancers.
bioRxiv · Jan 16, 2024Cancer Biology