J. Ma

Dynamic Regulation of Innate Lymphoid Cell Development During Ontogeny

This study investigates the developmental changes in innate lymphoid cell (ILC) subsets using scRNA-seq and differentiation assays, revealing distinct regulatory programs in fetal and adult stages.

Deterministic processes played more important roles than stochastic processes in driving community assembly of ectomycorrhizal fungal associated with Pinus tabuliformis - an endemic Pinaceae species in China

The study examines EM fungal communities associated with Pinus tabuliformis, finding deterministic processes dominate community assembly over stochastic processes.

Mealtime alters daily rhythm in nuclear O-GlcNAc proteome to regulate hepatic gene expression

This study shows that mealtime affects the daily rhythm of nuclear O-GlcNAc proteome in mice, which regulates hepatic gene expression through interactions with phosphorylation.

Combining Scalable Organ Chip Platform with Deep Learning-Based Imaging Analysis for Cancer Therapeutic Screening

The paper combines an organ chip platform with deep learning for drug response analysis in cancer models, showing improved accuracy over traditional methods.

Determinants of de novo mutations in extended pedigrees of 43 dog breeds

The paper investigates mutation rates in 43 dog breeds, finding stable rates influenced by parental age and breed-specific differences in mutation accumulation.

Horizontally acquired CSP genes contribute to wheat adaptation and improvement

This study identifies horizontally acquired CSP genes in wheat that enhance drought tolerance and photosynthetic efficiency, contributing to wheat adaptation and improvement.

P-cadherin mechanoactivates tumor- mesothelium metabolic coupling to promote ovarian cancer metastasis

This study shows that P-cadherin-mediated mechanical forces on mesothelial cells enhance lipid production in ovarian cancer cells, promoting metastasis through lactate-driven lipogenesis.

Parallel Analyses by Mass Spectrometry (MS) and Reverse Phase Protein Array (RPPA) Reveal Complementary Proteomic Profiles in Triple-Negative Breast Cancer (TNBC) Patient Tissues and Cell Cultures

The paper compares Mass Spectrometry (MS) and Reverse Phase Protein Array (RPPA) in TNBC samples to assess their performance and identify complementary proteomic profiles.

Genome sequencing of 'Fuji' apple clonal varieties reveals evolutionary history and genetic mechanism of the spur-type morphology

The paper sequenced clonal Fuji apple varieties to uncover somatic variants linked to spur-type morphology and early maturation traits.

Gradual labeling with fluorogenic probes for MINFLUX nanoscopy of densely packed structures

This paper introduces GLF-MINFLUX, a method for nanoscale imaging of densely packed structures, achieving improved localization precision and faster acquisition.

Investigation of the mechanism of accelerated biodegradation of Paracoccus-KDSPL-02

This study identifies PROKKA_01468 as a photoreceptor protein in Paracoccus-KDSPL-02 that enhances penicillin G degradation under light.

Metabolic enzymes moonlight as selective autophagy receptors to protect plants against viral-induced cellular damage

This study shows that metabolic enzymes act as autophagy receptors in plants to degrade defense executors during viral infection, revealing autophagy as a tolerance pathway rather than an antiviral defense.

The genomic consequences and persistence of sociality in spiders

This study investigates the genomic consequences of sociality in spiders, finding that transitions to sociality lead to reduced effective population size and genomic diversity, potentially causing extinction.

SHP-1 interacts with NFκB1 to inhibit its phosphorylation and nuclear translocation to suppress excessive bacterial inflammation

This study shows SHP-1 interacts with NFκB1 to inhibit its phosphorylation and nuclear translocation, thereby suppressing bacterial inflammation in Chinese tongue sole.

Four centuries of commercial whaling eroded 11,000 years of population stability in bowhead whales

This study uses fossil data and modeling to show that commercial whaling caused genetic diversity loss in bowhead whales, threatening their resilience to future climate change.

Identification of cell-type-specific response to silicon treatment in soybean leaves through single nucleus RNA-sequencing

This study uses snRNA-seq to identify cell-type-specific responses to silicon treatment in soybean leaves, revealing novel Si-induced cell clusters and gene expression changes related to defense mechanisms.

EmbB and EmbC Regulate the Sensitivity of Mycobacterium abscessus to Echinomycin

This study identifies EmbB and EmbC as regulators of Mycobacterium abscessus sensitivity to echinomycin, showing that EmbB mutations can partially compensate for EmbC loss and alter cell wall permeability.

Mutations in ClpC1 or ClpX subunit of the caseinolytic protease confer resistance to natural product ilamycins in mycobacteria

This study identifies two ilamycin analogs targeting mycobacterial Clp protease components and discovers mutations conferring resistance to these compounds.

Regulatory divergences in dosage compensation cause hybrid male inviability in Caenorhabditis

Stimulated Prorocentrum donghaiense cell growth by in-situ mariculture dissolved organic matter

This study shows that in-situ mariculture dissolved organic matter promotes growth and photosynthesis of Prorocentrum donghaiense through absorbtrophy, with bacterioplankton playing helper and competitor roles.

The transcription factor Zeb2 drives differentiation of age-associated B cells

The paper identifies Zeb2 as a critical transcription factor driving age-associated B-cell differentiation and autoimmunity in humans and mice.

An Efficient and Safe Trans-complementation System for MPXV Mimicking Authentic Viral Infection

This paper develops a safe trans-complementation system for MPXV that mimics authentic infection, enabling research in lower biosafety labs without live virus.

Machine Learning Elucidates Design Features of Plasmid DNA Lipid Nanoparticles for Cell Type-Preferential Transfection

This study uses machine learning to identify LNP composition parameters that enhance transfection efficiency across cell types and modulate cell type-preferentiality.

Nucleolus and centromere TSA-Seq reveals variable localization of heterochromatin in different cell types

The paper uses TSA-seq to map genomic regions near nucleoli and pericentric heterochromatin in human cell lines, revealing variable heterochromatin localization and complex nuclear organization.

Human CD127 negative ILC2s show immunological memory

This study identifies CD127-negative ILC2s with immunological memory features in both healthy and inflamed tissues.

SART1 localizes to spindle poles forming a SART1 cap and promotes spindle pole assembly

This study identifies SART1 as a mitosis-specific microtubule-associated protein that localizes to spindle poles and recruits PCM proteins for spindle assembly.

Longer mandible or nose? Co-evolution of feeding organs in early elephantiforms

This study investigates the co-evolution of feeding organs in early elephantiforms, finding that feeding function shifted from the mandible to the trunk, enabling proboscideans to expand into new ecological niches.

Biogenic phosphonate utilization by globally distributed diatom Thalassiosira

This study shows that the diatom Thalassiosira pseudonana can use biogenic phosphonates as a phosphorus source, affecting its elemental stoichiometry and growth under phosphorus starvation.

Rapid Prototyping of Thermoplastic Microfluidic 3D Cell Culture Devices by Creating Regional Hydrophilicity Discrepancy

This paper develops a method to rapidly prototype thermoplastic microfluidic devices for 3D cell culture by creating regional hydrophilicity discrepancies, enabling dynamic cell culture and drug screening.

Sound-based assembly of three-dimensional cellularized and acellularized constructs

This paper demonstrates a technique using Faraday waves to assemble 3D cellularized and acellular constructs with osteoinductive properties.