K. Jones

Mutation and cell state compatibility is required and targetable in Ph+ acute lymphoblastic leukemia minimal residual disease

This study identifies mutation and transcriptional state compatibility in Ph+ ALL MRD, showing that targeting these interactions can overcome BCR::ABL1 independence and improve MRD monitoring.

Global overview of sea turtle fibropapillomatosis tumors: a survey of expert opinions and trends.

This study surveys global experts on sea turtle fibropapillomatosis to assess disease trends, treatment approaches, and research needs.

Targeting Diffuse Midline Glioma with a novel anti-CD99 Antibody

This paper identifies CD99 as a therapeutic target in K27M+DMGs, showing that a novel anti-CD99 antibody reduces tumor growth and enhances radiation efficacy in preclinical models.

Intrauterine Growth-Restricted Pregnant Rats, from Hypertensive Placental Ischemic Dams Display Preeclamptic-like Symptoms: A New Rodent Model of Preeclampsia

This study establishes a new rodent model of preeclampsia by inducing intrauterine growth restriction in pregnant rats, showing elevated blood pressure and oxidative stress.

Somatic gene delivery for flexible in vivo modeling of high-risk sarcoma

This paper develops a mouse model for high-risk sarcoma by delivering genetic lesions via electroporation, generating multiple sarcoma types and validating their molecular and therapeutic relevance.

TKI Type Switching Overcomes ROS1 L2086F in ROS1 Fusion-Positive Cancers

This study shows that type II TKIs cabozantinib and merestinib, and type I FLT3 inhibitor gilteritinib, inhibit ROS1 L2086F mutant kinase, overcoming resistance to type I TKIs in ROS1 fusion-positive cancers.

Project ChemicalBlooms: Collaborating with Citizen Scientists to Survey the Chemical Diversity and Phylogenetic Distribution of Plant Epicuticular Wax Blooms

The paper surveys plant epicuticular wax blooms using citizen scientists, finding lineage-specific chemical patterns and suggesting non-biosynthetic mechanisms for triterpenoid-rich blooms.

Tissue-resident NK cells support survival in pancreatic cancer through promotion of cDC1-CD8T activity

The paper shows that ionizing radiation enhances immunotherapy in pancreatic cancer by increasing tissue-resident NK cells that support CD8 T cell activity through cDC1-dependent mechanisms.

PD-L1 Restrains the PD-1hiNrp1loTGFb+ Treg to block IL6+ Neutrophil tumor infiltration to Suppress Inflammation-driven Colorectal Cancer

This study shows PD-L1 suppresses inflammation-driven colorectal cancer by regulating Tregs, neutrophils, and gut microbiota through the PD-L1/L. murinus/PD-1hiNrp1loTGFβ+ Treg/IL6+ neutrophils pathway.

Discovery of oncogenic ROS1 missense mutations with sensitivity to tyrosine kinase inhibitors

The paper identifies oncogenic ROS1 missense mutations that are sensitive to tyrosine kinase inhibitors, showing their potential as therapeutic targets.

Immunoglobulin M regulates airway hyperresponsiveness independent of T helper 2 allergic inflammation.

This study shows IgM regulates airway hyperresponsiveness independently of Th2 inflammation in a mouse model of allergic asthma.

The impact of vaccine-linked chemotherapy on liver health in a mouse model of chronic Trypanosoma cruzi infection

This study evaluates the impact of vaccine-linked chemotherapy on liver health in a mouse model of chronic Trypanosoma cruzi infection, finding that the treatment better preserves liver health compared to curative doses of benznidazole.

Isolation by environment is more important than isolation by distance along a tropical gradient in direct developing frogs

This study quantifies the role of abiotic factors over geographic distance in driving genetic divergence in direct-developing frogs along an elevation gradient.

Benchmarking robust spatial transcriptomics approaches to capture the molecular landscape and pathological architecture of archived cancer tissues

This study benchmarks spatial transcriptomics methods on archived FFPE cancer tissues, revealing molecular landscapes and pathological features, including non-coding RNA expression.

A 3D adrenocortical carcinoma tumor platform for preclinical modeling of drug response and matrix metalloproteinase activity

This paper develops a 3D adrenocortical carcinoma tumor platform to study drug response and MMP activity, showing decreased drug sensitivity and active MMP-mediated invasion in 3D.

Regulated Induced Proximity Targeting Chimeras (RIPTACs): a Novel Heterobifunctional Small Molecule Therapeutic Strategy for Killing Cancer Cells Selectively

This paper introduces RIPTACs, a new class of heterobifunctional small molecules that selectively kill cancer cells by inducing protein-protein interactions that disrupt essential cellular functions.

Mutation in the matricellular gene fibulin-4 leads to endothelial dysfunction in resistance arteries

This study shows that fibulin-4 mutations cause endothelial dysfunction in resistance arteries due to increased shear stress and oxidative environment.

Differential transcriptomic responses to heat stress in surface and subterranean diving beetles

This study compares heat stress transcriptomic responses between a surface and subterranean diving beetle, finding the surface species mounts a more robust response with greater gene expression changes.

Experimental infection of specific-pathogen-free domestic lambs with Mycoplasma ovipneumoniae causes asymptomatic colonization of the upper airways that is resistant to antibiotic treatment

This study infects domestic lambs with Mycoplasma ovipneumoniae and finds asymptomatic upper respiratory tract colonization resistant to antibiotics and immune clearance.

The regenerating skeletal muscle niche guides muscle stem cell self-renewal

This study identifies the timing and cellular processes of muscle stem cell self-renewal during regeneration, showing that the regenerating niche drives this process through non-cell autonomous signaling.

Spatial analysis of ligand-receptor interaction in skin cancer at genome-wide and single-cell resolution

The paper develops a toolbox to study cancer-immune cell communication using multimodal data and a computational method called STRISH, validated on basal and squamous cell carcinomas.

The Species Awareness Index (SAI): a Wikipedia-derived conservation culturomics metric for public biodiversity awareness

The paper introduces the Species Awareness Index (SAI) to measure public biodiversity awareness using Wikipedia data, finding increasing awareness overall but varying by taxonomic class and language.

Disease Risk Analysis in sea turtles: A baseline study to inform conservation efforts

This study conducts a disease risk analysis for all seven sea turtle species, identifying knowledge gaps and suggesting management strategies for conservation.

Heterogeneity and targeted therapy-induced adaptations in lung cancer revealed by longitudinal single-cell RNA sequencing

This study uses longitudinal single-cell RNA sequencing to reveal therapy-induced adaptations in lung cancer, identifying cell state transitions and pathways associated with treatment response and resistance.

Differential effects of emerging broad-spectrum streetlight technologies on landscape-scale bat activity

This study analyzes the impact of different streetlight technologies on bat activity across Jersey, finding negative effects of LED and HPS lights but not MH lights, while highlighting urbanization and road type as larger factors.

Doublecotin-like kinase 1 increases chemoresistance of colorectal cancer cells through the anti-apoptosis pathway

This study shows that DCLK1 overexpression in colorectal cancer cells increases chemoresistance to 5-Fu by suppressing caspase gene expression and inhibiting apoptosis.

Comprehensive Immune Monitoring of Clinical Trials to Advance Human Immunotherapy

The paper presents a mass cytometry workflow for standardized immune monitoring in immunotherapy trials, identifying immune cell signatures and validating its robustness across samples and centers.

The hyperstability and composition of Giardias ventral disc highlights the remarkable versatility of microtubule organelles

The paper identifies 54 new disc-associated proteins in Giardia's ventral disc and shows its hyperstable microtubule array is stabilized by novel and conserved proteins.

Robust and stable transcriptional repression in Giardia using CRISPRi

This study develops CRISPRi for stable transcriptional repression in Giardia, demonstrating efficient gene knockdown and phenotypic effects.

Disruption of the interfacial membrane leads to Magnaporthe oryzae effector re-location and lifestyle switch during rice blast disease

This study shows that disruption of the EIHM in Magnaporthe oryzae leads to effector re-location and a lifestyle switch during rice blast disease, identifying key infection phases and host cell responses.