Failed reprogramming of transformed cells due to induction of apoptosis and senescence impairs tumor progression in lung cancer
P. Pedrosa, Z. Zang, D. Macias, J. Ge, M. Denholm, A. Dyas, V. Nunez-Quintela, V. Estevez-Souto, P. Lado-Fernandez, P. Gonzalez, M. Gomez, J. E. Martin, S. Da Silva-Alvarez, D. Munoz-Espin, M. Collado
The paper shows that OSKM expression in lung cancer cells induces apoptosis and senescence, limiting tumor growth and reducing tumor burden in vivo.
bioRxiv · Oct 19, 2023 · PreprintCell Biology