J. Ge

Single molecule studies of the native hair cell mechanosensory transduction complex

This study optimizes single molecule assays to detect and quantify the native hair cell mechanosensory transduction complex at attomole levels.

Dendritic cell-derived lncRNA in patients with acute coronary syndrome

This study examines lncRNA expression in monocyte-derived dendritic cells (moDC) across different ACS subtypes, identifying CCL15-CCL14 as a differentially expressed lncRNA that modulates moDC function.

Dilated cardiomyopathy mutation in beta-cardiac myosin enhances actin activation of the power stroke and phosphate release

This paper investigates how the E525K mutation in beta-cardiac myosin affects actin activation, power stroke, and phosphate release, revealing structural and kinetic changes linked to dilated cardiomyopathy.

M1 Macrophage-Related Genes Model for NSCLC Immunotherapy Response Prediction

This study develops a model using M1 macrophage-related genes to predict immunotherapy response and prognosis in advanced NSCLC patients.

Failed reprogramming of transformed cells due to induction of apoptosis and senescence impairs tumor progression in lung cancer

The paper shows that OSKM expression in lung cancer cells induces apoptosis and senescence, limiting tumor growth and reducing tumor burden in vivo.

Synergistic activity of rhamnolipid combined with linezolid against linezolid-resistant Enterococcus faecium

This study shows that rhamnolipids combined with linezolid synergistically enhance antibacterial activity against linezolid-resistant Enterococcus faecium through multiple assays and mouse models.

Biodecomposing Spirulina platensis by a de novo designed Bacillus subtilis-based method to develop a medium for the high cell-density cultivation of Escherichia coli in batch mode

This paper develops a method to biodecompose Spirulina platensis using Bacillus subtilis to create a medium for high cell-density cultivation of Escherichia coli, achieving higher growth rates and optical density than traditional LB broth.

Membrane remodeling properties of the Parkinson's disease protein LRRK2

This study shows that LRRK2 binds and remodels lipid membranes, suggesting its role in membrane dynamics and signaling.

Broadly neutralizing and protective nanobodies against diverse sarbecoviruses

The paper identifies nanobodies with broad neutralizing activity against multiple sarbecoviruses and shows their protective efficacy in a mouse model.

Quantitative Models of Lipid Transfer and Membrane Contact Formation

This paper reviews studies on lipid transfer proteins and develops quantitative models to explain lipid transfer kinetics and membrane contact site formation mechanisms.

Structural and computational insights into the SARS-CoV-2 Omicron RBD-ACE2 interaction

This study reports the crystal structure of the Omicron SARS-CoV-2 RBD-ACE2 complex and identifies key mutations enhancing ACE2 binding and immune escape.

SARS-CoV-2 hijacks neutralizing dimeric IgA for enhanced nasal infection and injury

This study shows that dimeric IgA antibodies can enhance SARS-CoV-2 nasal infection and injury in Syrian hamsters by engaging CD209 as an alternative receptor.

SARS-CoV-2 variants resist antibody neutralization and broaden host ACE2 usage

This study evaluates antibody resistance and ACE2 usage in SARS-CoV-2 variants, finding SA501Y.V2 shows the highest resistance and expanded host range.

Oxidized LDL but not angiotensin II induces the interaction between LOX-1 and AT1 receptors

This study shows Ox-LDL, not AngII, induces LOX-1 and AT1-R interaction, leading to cardiomyocyte hypertrophy via Gq protein activation.

Cardiomyopathy Mutations Impact the Power Stroke of Human Cardiac Myosin

This study investigates how cardiomyopathy mutations affect the power stroke of human cardiac myosin using FRET and kinetic measurements, revealing impaired structural changes and reduced force development.

Myofibroblast Forms Atherosclerotic Plaques

This study identifies myofibroblasts as the main contributors to atherosclerotic plaques by demonstrating their role in forming collagen fibers, foam cells, and extracellular lipids in vitro.

Potent human neutralizing antibodies elicited by SARS-CoV-2 infection

This study isolates and characterizes 206 RBD-specific monoclonal antibodies from SARS-CoV-2 infected individuals, finding diverse neutralizing activity and species-specific antibody responses.

Structure of RNA-dependent RNA polymerase from 2019-nCoV, a major antiviral drug target

The paper reports the cryo-EM structure of 2019-nCoV RdRp complexed with cofactors, revealing key residues and remdesivir binding, aiding antiviral drug design.

Crystal structure of the 2019-nCoV spike receptor-binding domain bound with the ACE2 receptor

The paper determines the crystal structure of the 2019-nCoV spike RBD bound to ACE2, revealing structural similarities to SARS-CoV and insights into antibody epitopes.

CaATP prolongs strong actomyosin binding and promotes futile myosin stroke

The paper investigates how CaATP prolongs actomyosin binding and promotes futile myosin strokes, contributing to muscle rigidity and thermogenesis in conditions like malignant hyperthermia.

Prognostic Role of c-Met Overexpression in High Grade Glioma: a Meta-analysis

This study evaluates the prognostic role of c-Met overexpression in high-grade glioma through meta-analysis and finds it correlates with poor progression-free survival but not overall survival.

Knowledge-guided analysis of ‘omics’ data using the KnowEnG cloud platform

KnowEnG is a cloud-based platform that provides tools for analyzing genomics data using knowledge-guided data-mining and machine learning, demonstrating its utility in cancer research.