Author

A. Earl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. L. Manson· 1 shared A. Pironti· 1 shared C. M. Ernst· 1 shared C. Mayerhofer· 1 shared C. Rhee· 1 shared D. Hung· 1 shared D. T. Scadden· 1 shared F. M. Duarte· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperEvolutionary Biology

A. L. Manson

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Author profile →

2 papers

Recent·Most cited

Cell of origin epigenetic priming determines susceptibility to Tet2 mutation

G. Schiroli, V. K. Kartha, F. M. Duarte, T. A. Kristiansen, C. Mayerhofer, R. Shrestha, A. Earl, Y. Hu, T. Tay, C. Rhee, J. Buenrostro, D. T. Scadden

The paper shows that the epigenetic state of the cell of origin influences susceptibility to Tet2 mutation, with Sox4 promoting dedifferentiation and increased clonal output in hematopoietic stem cells.

bioRxiv · Sep 4, 2023 · PreprintCancer Biology

Genetic determinants facilitating the evolution of resistance to carbapenem antibiotics

D. Hung, P. Ma, L. L. He, A. Pironti, H. H. Laibinis, C. M. Ernst, A. L. Manson, R. P. Bhattacharyya, A. Earl, J. Livny

This study identifies genetic factors that facilitate the evolution of carbapenem resistance in Klebsiella pneumoniae, highlighting transposon mutagenesis and mutation spectra as key contributors to resistance development.

bioRxiv · Feb 11, 2021Evolutionary Biology