P. Ma

Nuclear stiffening in neoplastic cells aggregates T cell exhaustion via pFAK/SP1/IL-6 axis in colorectal cancer

The paper shows that nuclear stiffening in colorectal cancer cells promotes T cell exhaustion through the pFAK/SP1/IL-6 axis, and inhibiting pFAK improves antitumor immunity.

Tabula Glycine: The whole-soybean single-cell resolution transcriptome atlas

The paper presents a single-cell transcriptome atlas of soybean, identifying 157 cell clusters and highlighting transcription factors' role in defining cell types and their origin.

Medium Composition Affects Microbial Corrosion Rates

The paper shows that medium composition affects microbial corrosion rates, with D. vulgaris outperforming D. ferrophilus in marine conditions despite initial assumptions about their mechanisms.

Elucidating Microbial Iron Corrosion Mechanisms with a Hydrogenase-Deficient Strain of Desulfovibrio vulgaris

This study investigates Fe0 corrosion by a hydrogenase-deficient mutant of Desulfovibrio vulgaris, showing H2 oxidation indirectly promotes corrosion via sulfide generation, not direct electron transfer.

CD40 is an immune checkpoint regulator that potentiates myocardial inflammation through activation and expansion of CCR2+ macrophages and CD8 T-cells

This study shows CD40 agonists promote myocardial inflammation by activating CCR2+ macrophages and CD8 T-cells, leading to heart failure.

Epithelial N-methyl-D-aspartate (NMDA) receptors mediate renal vasodilation by affecting kidney autoregulation.

This study identifies epithelial NMDA receptors in the kidney that mediate vasodilation via connecting-tubule-glomerular feedback by enhancing ENaC activity.

Expansion of Disease Specific Cardiac Macrophages in Immune Checkpoint Inhibitor Myocarditis

This study identifies an inflammatory macrophage population expanded in ICI myocarditis, driven by IFN-γ signaling and T-cell interactions, suggesting IFN-γ blockade as a potential therapeutic strategy.

Targeting the Immune-Fibrosis Axis in Myocardial Infarction and Heart Failure

The paper identifies a fibroblast trajectory associated with cardiac fibrosis and shows that macrophage-fibroblast crosstalk via IL-1β signaling drives fibrosis.

ULTRAFAST STRUCTURAL CHANGES DIRECT THE FIRST MOLECULAR EVENTS OF VISION

This study uses ultrafast crystallography to reveal how photoactivated retinal initiates structural changes in rhodopsin, leading to GPCR activation and vision.

Bacterial droplet-based single-cell RNA-seq reveals heterogeneity in bacterial populations and in response to antibiotic perturbation

BacDrop enables single-cell RNA-seq of bacteria, revealing population heterogeneity and differential responses to antibiotics in Klebsiella pneumoniae.

A transcriptional complex of FtMYB102 and FtbHLH4 coordinately regulates the accumulation of rutin in Fagopyrum tataricum

This study identifies FtMYB102 and FtbHLH4 as a transcriptional complex that promotes rutin accumulation in Tartary buckwheat by inducing CHI expression.

Single-nuclei transcriptomics of dog hippocampus reveals the distinct cellular mechanism of domestication

This study uses single-nuclei transcriptomics to analyze dog hippocampus cell types and identifies convergence between differentially expressed genes and putative positively selected genes related to nervous system development.

Multiplexed detection of bacterial nucleic acids using Cas13 in droplet microarrays

This paper introduces bCARMEN, a high-throughput system for rapid, multiplexed bacterial pathogen detection and antibiotic resistance gene identification using CRISPR-Cas13 and droplet microfluidics.

Exosomal miR-769-5p confers cisplatin resistance and tumorigenesis in gastric cancer

This study identifies exosomal miR-769-5p as a mediator of cisplatin resistance in gastric cancer by targeting CASP9 and promoting apoptosis evasion.

Classical swine fever virus NS5A inhibits NF-κB signaling by targeting NEMO

This paper identifies that NS5A of CSFV inhibits NF-κB signaling by degrading NEMO and blocking its k63-linked polyubiquitination.

Genetic determinants facilitating the evolution of resistance to carbapenem antibiotics

This study identifies genetic factors that facilitate the evolution of carbapenem resistance in Klebsiella pneumoniae, highlighting transposon mutagenesis and mutation spectra as key contributors to resistance development.

High throughput functional screening for next generation cancer immunotherapy using droplet-based microfluidics

This paper develops a droplet-based microfluidics platform for high-throughput functional antibody screening, identifying potent cancer immunotherapeutics like CD40 agonists and anti-Her2/anti-CD3 bispecific antibodies.

Potent SARS-CoV-2 neutralizing antibodies selected from a human antibody library constructed decades ago

The paper identifies potent SARS-CoV-2 neutralizing antibodies from a pre-pandemic human antibody library, showing high somatic hypermutation and specific binding to the spike protein.

SARS-CoV-2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis

This study shows SARS-CoV-2 infects human engineered heart tissues, causing myocarditis-like features, and identifies ACE2 and proteases as entry factors.

A visualizable hepatitis A virus and hepatitis C virus coinfection model in vitro: coexistence of two hepatic viruses under limited competition in viral RNA synthesis

This study establishes an in vitro model of HAV/HCV coinfection and finds mild reciprocal viral interference due to competition for rNTPs in RNA synthesis, suggesting indirect interactions explain HCV suppression in coinfected patients.

Biomechanical Analysis of Angular Motion in Association with Bilateral Semicircular Canal Function

This study develops a finite element model of bilateral human semicircular canals to analyze cupular expansion and deflection during head rotation, showing their mechanical roles in vestibular function.

Gut-innervating nociceptor neurons protect against enteric infection by modulating the microbiota and Peyer’s patch microfold cells

This study shows gut-innervating nociceptors protect against Salmonella typhimurium infection by modulating microbiota and Peyer’s patch microfold cells.

Comparative genome analysis of 12 Shigella sonnei strains: virulence, resistance, and their interactions

The paper analyzes 12 Shigella sonnei strains to compare virulence and antibiotic resistance, finding that resistant strains have more virulence factors and distinct genetic clusters.

Structural and biochemical characterization on the cognate and heterologous interactions of the MazEF-mt9 TA system

This study characterizes the structural and biochemical interactions of the MazEF-mt9 TA system in M. tb, revealing its cognate and heterologous antitoxin binding and its role in stress adaptation.