Y. Hu

Benchmarking RNA-seq Tools for Real-World Diagnostic Applications

This study benchmarks RNA-seq tools for diagnostic applications, finding they identify 28 diagnoses from 68 samples but only 9 out of 74 undiagnosed cases.

A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo

Integrating in silico predictions with an engineered tissue assay identifies Perlecan as an age-perturbed re-quiescence cue for muscle stem cells

The paper identifies Perlecan as a factor that influences muscle stem cell re-quiescence, showing its age-related changes and therapeutic potential.

Equip Fusobacterium nucleatum genetic tool kits with compatible shuttle vectors and engineered intermediatory E. coli strains for enhanced transformation efficiency

This paper develops genetic tools for Fusobacterium nucleatum by engineering E. coli intermediates and shuttle vectors, achieving 5000 transformants per microgram plasmid.

ClpP-dependent protein quality control supports antibiotic persistence in Campylobacter jejuni through bioenergetic homeostasis

This study identifies ClpP-dependent proteostasis as critical for antibiotic persistence in C. jejuni through bioenergetic homeostasis and metabolic remodeling.

Quantifying social roles in multi-animal videos using subject-aware deep-learning

This paper introduces a subject-aware deep-learning system to quantify social roles in multi-animal groups across species and assays.

IGF2BP3 promotes the progression of gastric cancer by activating cGMP-PKG signaling pathway via targeting FBXO32

This study identifies IGF2BP3 as a promoter of gastric cancer progression by upregulating FBXO32 via m6A binding and activating the cGMP-PKG signaling pathway.

Systemic delivery of murine SOD2 mRNA to experimental abdominal aortic aneurysm mitigates expansion and rupture

This study delivers SOD2 mRNA via nanoparticles to mice with abdominal aortic aneurysms, reducing aneurysm expansion and rupture by enhancing antioxidant activity and modulating inflammatory pathways.

Reversible kink instability drives ultrafast jumping in nematodes and soft robots

This paper demonstrates that a reversible kink instability in nematodes enhances jumping performance and proposes a bio-inspired model for soft robots.

CLCC1 Governs Bilayer Equilibration at the Endoplasmic Reticulum to Maintain Cellular and Systemic Lipid Homeostasis

This study identifies CLCC1 as a key regulator of phospholipid trans-bilayer equilibration at the ER, essential for lipid homeostasis and preventing metabolic diseases.

Ephrin Forward Signaling Controls Interspecies Cell Competition in Pluripotent Stem Cells

This study identifies Ephrin A ligands in mouse cells as mediators of cell death signaling to human pluripotent stem cells during interspecies co-culture, enhancing chimera formation when inhibited.

Genome sequencing of 'Fuji' apple clonal varieties reveals evolutionary history and genetic mechanism of the spur-type morphology

The paper sequenced clonal Fuji apple varieties to uncover somatic variants linked to spur-type morphology and early maturation traits.

Influences of single mutation and retinal binding on the THz absorption spectra of CRABP-II based rhodopsin mimics

This study uses THz-TDS to analyze how retinal binding and single mutations affect the low-frequency absorption spectra of rhodopsin mimics.

Biochemical and structural insights into a 5' to 3' RNA ligase reveal a potential role in tRNA ligation

This study identifies C12orf29 as an RNA ligase that ligates tRNA and alters tRNA levels in mice, with structural insights into its catalytic mechanism.

Natural variation in salt-induced changes in root:shoot ratio reveals SR3G as a negative regulator of root suberization and salt resilience in Arabidopsis

Transcriptome Analysis Reveals Long-Term Somatic Memory of Stress in The Woody Perennial Crop, Grapevine Vitis Vinifera cv. Cabernet Sauvignon

This study investigates stress memory in grapevines using transcriptome and methylome sequencing, finding epigenetic changes and a classification model for stress memory genes.

Histone deacetylases regulate organ-specific growth in a horned beetle

This study investigates the role of histone deacetylases (HDACs) in regulating organ-specific growth in the horned dung beetle Onthophagus taurus under varying nutritional conditions.

A peptide targeting outer membrane protein A of Acinetobacter baumannii exhibits antibacterial activity by reducing bacterial pathogenicity

This paper identifies a peptide, P92, that targets AbOmpA of A. baumannii, reducing bacterial pathogenicity without inhibiting growth, showing efficacy in multiple infection models.

Molecular stratification of human fetal vaginal epithelium by spatial transcriptome analysis

This study uses spatial transcriptomics to classify human fetal vaginal epithelium into four zones, identifying distinct gene expression patterns and potential differentiation trajectories.

Development of an engineered extracellular vesicles-based vaccine platform for combined delivery of mRNA and protein to induce functional immunity

This paper develops an engineered extracellular vesicles-based vaccine platform for combined mRNA and protein delivery, showing tumor regression and immune responses in preclinical models.

Multivalent 28S rRNA Is the Organizer of the Nucleolus's Multi-layered Architecture

This study identifies 28S rRNA as a key organizer of the tripartite nucleolus structure through multivalent interactions that drive the formation of the three-layered architecture.

DNA-based ForceChrono Probes for Deciphering Single-Molecule Force Dynamics in Living Cells

This paper introduces DNA-based ForceChrono probes to measure single-molecule force dynamics in living cells, revealing precise loading rates and a link between force magnitude and duration.

RGS10 deficiency facilitates distant metastasis by inducing epithelial-mesenchymal transition in breast cancer

This study shows RGS10 deficiency promotes breast cancer metastasis via EMT by mechanisms involving lipocalin-2 and miR-539-5p.

Thermal Characterization and Preclinical Validation of an Accessible, Carbon Dioxide-Based Cryotherapy System

This study evaluates a carbon dioxide-based cryotherapy device for breast cancer treatment, showing its ablation zone size is comparable to an argon-based device in a shorter treatment time.

Visualizing the M2 muscarinic acetylcholine receptor activation regulated by aromatic ring dynamics

This study uses atomic-level simulations to show how ligand binding modulates conformational dynamics of the M2 muscarinic receptor, revealing key aromatic residue interactions involved in activation.

Interplay between Mg2+ and Ca2+ at multiple sites of the ryanodine receptor

The paper determines cryo-EM structures of RyR1 with Mg2+ and identifies multiple Mg2+ binding sites, revealing its inhibitory mechanism and interaction with gating helices.

R-Loop Functions in Brca1-Associated Mammary Tumorigenesis

This study shows that reducing R-loops in Brca1-knockout mice increases ER-expressing tumors but does not affect tumor incidence.

Inhibiting YAP1 reduced abdominal aortic aneurysm formation by suppressing adventitial fibroblast phenotype transformation and migration

This study shows that inhibiting YAP1 reduces abdominal aortic aneurysm formation by preventing adventitial fibroblast transformation into myofibroblasts and migration.

Dispersal and evolution of the invasive snail Pomacea canaliculata, an intermediate host of Angiostrongylus cantonensis: A field study around its initial introduction site in China

This study investigates the spatial distribution, phenotypic variation, and dispersal patterns of the invasive snail Pomacea canaliculata in China, revealing human-mediated evolution and potential complexities in parasite transmission.

SntB triggers the antioxidant pathways to regulate development and aflatoxin biosynthesis in Aspergillus flavus

This study identifies SntB as a regulator of growth, development, and aflatoxin biosynthesis in Aspergillus flavus by modulating antioxidant pathways and gene expression.