MFSD1 in complex with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes
K. E. J. Jungnickel, O. Guelle, M. Iguchi, W. Dong, V. Kotov, F. Gabriel, C. Debacker, J. Dairou, I. McCort-Tranchepain, N. N. Laqtom, S. H. Chan, A. Ejima, K. Sato, D. Massa Lopez, P. Saftig, , M. Damme
The paper identifies MFSD1 as a lysosomal dipeptide uniporter that facilitates the transport of cationic and neutral dipeptides when amino acid exporters are overloaded.
Nature Cell Biology · Jun 5, 2024Peer-reviewedBiochemistry